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Gene Review

Itsn1  -  intersectin 1 (SH3 domain protein 1A)

Mus musculus

Synonyms: AA517634, AA545208, AI316805, AI839402, AI848451, ...
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High impact information on Itsn1


Biological context of Itsn1


Anatomical context of Itsn1

  • In platelet-derived growth factor-stimulated Swiss 3T3 cells, intersectin co-localizes with CdGAP and inhibits its GAP activity toward Rac1 [7].

Associations of Itsn1 with chemical compounds

  • Thus, we propose a model in which intersectin binding results in a change of CdGAP conformation involving the proline-rich domain that leads to the inhibition of its GAP activity [7].
  • Cloning of full-length cDNAs revealed that EHSH1 is composed of an N-terminal region with two EH domains, a central region that is enriched in lysine, leucine, glutamate, arginine, and glutamine (KLERQ domain), and a C-terminal region comprised of five SH3 domains [4].

Analytical, diagnostic and therapeutic context of Itsn1


  1. EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP. Irie, F., Yamaguchi, Y. Nat. Neurosci. (2002) [Pubmed]
  2. Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis. Zamanian, J.L., Kelly, R.B. Mol. Biol. Cell (2003) [Pubmed]
  3. Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. Cabral, A., Fischer, D.F., Vermeij, W.P., Backendorf, C. J. Biol. Chem. (2003) [Pubmed]
  4. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? Okamoto, M., Schoch, S., Südhof, T.C. J. Biol. Chem. (1999) [Pubmed]
  5. Alternative splicing of mammalian Intersectin 1: domain associations and tissue specificities. Tsyba, L., Skrypkina, I., Rynditch, A., Nikolaienko, O., Ferenets, G., Fortna, A., Gardiner, K. Genomics (2004) [Pubmed]
  6. Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1. Kim, J.H., Wilder, P.J., Hou, J., Nowling, T., Rizzino, A. J. Biol. Chem. (2002) [Pubmed]
  7. The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin. Jenna, S., Hussain, N.K., Danek, E.I., Triki, I., Wasiak, S., McPherson, P.S., Lamarche-Vane, N. J. Biol. Chem. (2002) [Pubmed]
  8. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. Sengar, A.S., Wang, W., Bishay, J., Cohen, S., Egan, S.E. EMBO J. (1999) [Pubmed]
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