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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

tps-2  -  Protein TPS-2

Caenorhabditis elegans

 
 
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High impact information on tps-2

  • Strong loss-of-function mutants in the C. elegans tps-1 and tps-2 genes (which encode the two trehalose phosphate synthases responsible for trehalose-6-phosphate synthesis) completely suppress the lethality associated with gob-1 loss of function [1].
  • Sorbitol suppresses the growth defect in the tps1 and tps2 mutants at 37 degrees C, which supports the hypothesis that these sugars (trehalose and sorbitol) act primarily as stress protectants for proteins and membranes during exposure to high temperatures in C. neoformans [2].
  • The A. avenae genes encode very similar proteins containing the catalytic domain characteristic of the GT-20 family of glycosyltransferases and are most similar to tps-2 of C. elegans; no evidence was found for a gene in A. avenae corresponding to Ce-tps-1 [3].
  • Analysis of A. avenae tps cDNAs revealed several features of interest, including alternative trans-splicing of spliced leader sequences in Aav-tps-1, and four different, novel SL1-related trans-spliced leaders, which were different to the canonical SL1 sequence found in all other nematodes studied [3].

References

  1. The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase. Kormish, J.D., McGhee, J.D. Dev. Biol. (2005) [Pubmed]
  2. Characterization and Regulation of the Trehalose Synthesis Pathway and Its Importance in the Pathogenicity of Cryptococcus neoformans. Petzold, E.W., Himmelreich, U., Mylonakis, E., Rude, T., Toffaletti, D., Cox, G.M., Miller, J.L., Perfect, J.R. Infect. Immun. (2006) [Pubmed]
  3. Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins. Goyal, K., Browne, J.A., Burnell, A.M., Tunnacliffe, A. Biochimie (2005) [Pubmed]
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