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Chemical Compound Review

AC1L9GQI     [(2R,3S,4S,5R)-3,4,5- trihydroxy-6-[(2S,3R...

Synonyms: 1byk, T6P
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Disease relevance of trehalose-6-phosphate


High impact information on trehalose-6-phosphate


Biological context of trehalose-6-phosphate


Associations of trehalose-6-phosphate with other chemical compounds


Gene context of trehalose-6-phosphate


Analytical, diagnostic and therapeutic context of trehalose-6-phosphate


  1. Trehalose-6-phosphate phosphorylase is part of a novel metabolic pathway for trehalose utilization in Lactococcus lactis. Andersson, U., Levander, F., Rådström, P. J. Biol. Chem. (2001) [Pubmed]
  2. Expression of a bifunctional fusion of the Escherichia coli genes for trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase in transgenic rice plants increases trehalose accumulation and abiotic stress tolerance without stunting growth. Jang, I.C., Oh, S.J., Seo, J.S., Choi, W.B., Song, S.I., Kim, C.H., Kim, Y.S., Seo, H.S., Choi, Y.D., Nahm, B.H., Kim, J.K. Plant Physiol. (2003) [Pubmed]
  3. Three enzymes for trehalose synthesis in Bradyrhizobium cultured bacteria and in bacteroids from soybean nodules. Streeter, J.G., Gomez, M.L. Appl. Environ. Microbiol. (2006) [Pubmed]
  4. Trehalose-6-phosphate Phosphatase from Mycobacterium tuberculosis induces humoral and cellular immune responses. Zhang, M., Yang, Y., Xu, Y., Qie, Y., Wang, J., Zhu, B., Wang, Q., Jin, R., Xu, S., Wang, H. FEMS Immunol. Med. Microbiol. (2007) [Pubmed]
  5. Trehalose metabolism: a regulatory role for trehalose-6-phosphate? Eastmond, P.J., Graham, I.A. Curr. Opin. Plant Biol. (2003) [Pubmed]
  6. Roles of trehalose phosphate synthase in yeast glycogen metabolism and sporulation. De Silva-Udawatta, M.N., Cannon, J.F. Mol. Microbiol. (2001) [Pubmed]
  7. The orlA gene from Aspergillus nidulans encodes a trehalose-6-phosphate phosphatase necessary for normal growth and chitin synthesis at elevated temperatures. Borgia, P.T., Miao, Y., Dodge, C.L. Mol. Microbiol. (1996) [Pubmed]
  8. Cleavage of trehalose-phosphate in Bacillus subtilis is catalysed by a phospho-alpha-(1-1)-glucosidase encoded by the treA gene. Helfert, C., Gotsche, S., Dahl, M.K. Mol. Microbiol. (1995) [Pubmed]
  9. Trehalose metabolism in Escherichia coli: stress protection and stress regulation of gene expression. Strøm, A.R., Kaasen, I. Mol. Microbiol. (1993) [Pubmed]
  10. Synergy between trehalose and Hsp104 for thermotolerance in Saccharomyces cerevisiae. Elliott, B., Haltiwanger, R.S., Futcher, B. Genetics (1996) [Pubmed]
  11. Crystal structure of trehalose-6-phosphate phosphatase-related protein: biochemical and biological implications. Rao, K.N., Kumaran, D., Seetharaman, J., Bonanno, J.B., Burley, S.K., Swaminathan, S. Protein Sci. (2006) [Pubmed]
  12. The function of trehalose biosynthesis in plants. Wingler, A. Phytochemistry (2002) [Pubmed]
  13. Nitrogen starvation in a Saccharomyces cerevisiae strain deleted in the trehalose-6-phosphate synthase complex. Fernandes, P.M., Trugo, L.C., Panek, A.D. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  14. Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism. Wang, R., Okamoto, M., Xing, X., Crawford, N.M. Plant Physiol. (2003) [Pubmed]
  15. Trehalose transport and metabolism in Escherichia coli. Boos, W., Ehmann, U., Forkl, H., Klein, W., Rimmele, M., Postma, P. J. Bacteriol. (1990) [Pubmed]
  16. Characterization of a cytoplasmic trehalase of Escherichia coli. Horlacher, R., Uhland, K., Klein, W., Ehrmann, M., Boos, W. J. Bacteriol. (1996) [Pubmed]
  17. Uncoupling of the glucose growth defect and the deregulation of glycolysis in Saccharomyces cerevisiae Tps1 mutants expressing trehalose-6-phosphate-insensitive hexokinase from Schizosaccharomyces pombe. Bonini, B.M., Van Dijck, P., Thevelein, J.M. Biochim. Biophys. Acta (2003) [Pubmed]
  18. Trehalose-6-phosphate synthase 1, which catalyses the first step in trehalose synthesis, is essential for Arabidopsis embryo maturation. Eastmond, P.J., van Dijken, A.J., Spielman, M., Kerr, A., Tissier, A.F., Dickinson, H.G., Jones, J.D., Smeekens, S.C., Graham, I.A. Plant J. (2002) [Pubmed]
  19. The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase. Kormish, J.D., McGhee, J.D. Dev. Biol. (2005) [Pubmed]
  20. Molecular cloning and physical mapping of the otsBA genes, which encode the osmoregulatory trehalose pathway of Escherichia coli: evidence that transcription is activated by katF (AppR). Kaasen, I., Falkenberg, P., Styrvold, O.B., Strøm, A.R. J. Bacteriol. (1992) [Pubmed]
  21. Role of trehalose biosynthesis in environmental survival and virulence of Salmonella enterica serovar typhimurium. Howells, A.M., Bullifent, H.L., Dhaliwal, K., Griffin, K., García de Castro, A., Frith, G., Tunnacliffe, A., Titball, R.W. Res. Microbiol. (2002) [Pubmed]
  22. Presence of two trehalose-6-phosphate synthase enzymes in Candida utilis. Vicente-Soler, J., Arguelles, J.C., Gacto, M. FEMS Microbiol. Lett. (1989) [Pubmed]
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