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Gene Review

Drep-1  -  DNA fragmentation factor-related protein 1

Drosophila melanogaster

Synonyms: CG8357, DREP-1, DREP-1/dICAD, Dmel\CG8357, Drep1, ...
 
 
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High impact information on Rep1

  • The expression of these genes was further enhanced in flies lacking both dICAD and DNase II [1].
  • We next examined whether Draper is responsible for the phagocytosis of apoptotic cells in vivo using an assay for engulfment based on assessing DNA degradation of apoptotic cells in dICAD mutant embryos (which only occurred after ingestion by the phagocytes) [2].
  • When a Drosophila neuronal cell line was induced to apoptosis by treatment with a kinase inhibitor, both dCAD and dICAD were cleaved [3].
  • The expression of the caspase-resistant form of dICAD/DREP-1 in a Drosophila neuronal cell line prevented the apoptotic DNA fragmentation [4].
 

Biological context of Rep1

  • The recombinant DREP-1/dICAD was cleaved at a specific site by human caspase 3 as well as by extracts prepared from S2 cells undergoing apoptosis [4].
 

Physical interactions of Rep1

References

  1. Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation. Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., Nagata, S. Genes Dev. (2002) [Pubmed]
  2. Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages. Manaka, J., Kuraishi, T., Shiratsuchi, A., Nakai, Y., Higashida, H., Henson, P., Nakanishi, Y. J. Biol. Chem. (2004) [Pubmed]
  3. A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster. Yokoyama, H., Mukae, N., Sakahira, H., Okawa, K., Iwamatsu, A., Nagata, S. J. Biol. Chem. (2000) [Pubmed]
  4. Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogaster. Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., Sakahira, H., Nagata, S. J. Biol. Chem. (2000) [Pubmed]
 
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