Chemical Compound Review:
Lopac-D-104 (1,1-dimethyl-3,4,5,6- tetrahydro-2H...
Synonyms:
Tocris-0482, AG-K-20073, SureCN2730650, CHEBI:73467, CHEBI:376139, ...
- Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon. Sawyer, G.W., Ehlert, F.J. J. Pharmacol. Exp. Ther. (1998)
- Pulmonary pharmacology of a novel, smooth muscle-selective muscarinic antagonist in vivo. Howell, R.E., Laemont, K.D., Kovalsky, M.P., Lowe, V.C., Waid, P.P., Kinnier, W.J., Noronha-Blob, L. J. Pharmacol. Exp. Ther. (1994)
- Function of M3 muscarinic receptors in the rat urinary bladder following partial outlet obstruction. Krichevsky, V.P., Pagala, M.K., Vaydovsky, I., Damer, V., Wise, G.J. J. Urol. (1999)
- Functional characterization of peripheral muscarinic subtypes in anesthetized cats. Koss, M.C. Life Sci. (1997)
- Study of the muscarinic receptor subtypes in N1E 115 mouse neuroblastoma cells. Fraeyman, N.H., Buyse, M.A., Lefebvre, R.A. Pharmacol. Res. (1991)
- M2 muscarinic receptor subtype in the feline medial pontine reticular formation modulates the amount of rapid eye movement sleep. Baghdoyan, H.A., Lydic, R. Sleep. (1999)
- Characterization of muscarinic receptor subtypes in the rostral ventrolateral medulla and effects on morphine-induced antinociception in rats. Abe, K., Taguchi, K., Kato, M., Utsunomiya, I., Chikuma, T., Hojyo, H., Miyatake, T. Eur. J. Pharmacol. (2003)
- Inhibition of the morphine withdrawal syndrome by a novel muscarinic antagonist (4-DAMP). Buccafusco, J.J. Life Sci. (1991)
- Effect of cholinergic agonists on gastrin release from primary cultures of human antral G cells. Koop, I., Squires, P.E., Meloche, R.M., Buchan, A.M. Gastroenterology (1997)
- Identification of muscarinic M2 receptors on single muscle cells of the human and guinea pig intestine. Grider, J.R., Bitar, K.N., Makhlouf, G.M. Gastroenterology (1987)
- The molecular and pharmacological properties of muscarinic cholinergic receptors expressed by rat sweat glands are unaltered by denervation. Grant, M.P., Landis, S.C., Siegel, R.E. J. Neurosci. (1991)
- Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq. Murthy, K.S., Makhlouf, G.M. J. Biol. Chem. (1997)
- Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Zhang, H.M., Chen, S.R., Matsui, M., Gautam, D., Wess, J., Pan, H.L. Mol. Pharmacol. (2006)
- Acetylcholine-induced desensitization of the contractile response to histamine in Guinea pig ileum is prevented by either pertussis toxin treatment or by selective inactivation of muscarinic M(3) receptors. Shehnaz, D., Ansari, K.Z., Ehlert, F.J. J. Pharmacol. Exp. Ther. (2001)
- Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum. Sawyer, G.W., Lambrecht, G., Ehlert, F.J. Br. J. Pharmacol. (2000)
- Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues. Thomas, E.A., Hsu, H.H., Griffin, M.T., Hunter, A.L., Luong, T., Ehlert, F.J. Mol. Pharmacol. (1992)
- Receptor-coupled phosphoinositide hydrolysis in human retinal pigment epithelium. Feldman, E.L., Randolph, A.E., Johnston, G.C., DelMonte, M.A., Greene, D.A. J. Neurochem. (1991)
- Characterization of the muscarinic receptors in the mesenteric vascular bed of spontaneously hypertensive rats. Hendriks, M.G., Pfaffendorf, M., van Zwieten, P.A. J. Hypertens. (1993)
- Muscarinic receptor subtypes in human nasal mucosa: characterization, autoradiographic localization, and function in vitro. Okayama, M., Mullol, J., Baraniuk, J.N., Hausfeld, J.N., Feldman, B., Merida, M., Shelhamer, J.H., Kaliner, M.A. Am. J. Respir. Cell Mol. Biol. (1993)
- Muscarinic receptors mediating depression and long-term potentiation in rat hippocampus. Auerbach, J.M., Segal, M. J. Physiol. (Lond.) (1996)
- Drosophila nervous system muscarinic acetylcholine receptor: transient functional expression and localization by immunocytochemistry. Blake, A.D., Anthony, N.M., Chen, H.H., Harrison, J.B., Nathanson, N.M., Sattelle, D.B. Mol. Pharmacol. (1993)
- Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Patel, H.J., Barnes, P.J., Takahashi, T., Tadjkarimi, S., Yacoub, M.H., Belvisi, M.G. Am. J. Respir. Crit. Care Med. (1995)
- Characterization of the muscarinic receptor subtype involved in phosphoinositide metabolism in bovine tracheal smooth muscle. Roffel, A.F., Meurs, H., Elzinga, C.R., Zaagsma, J. Br. J. Pharmacol. (1990)
- PC12 phaeochromocytoma cells contain an atypical muscarinic receptor binding site. Michel, A.D., Stefanich, E., Whiting, R.L. Br. J. Pharmacol. (1989)
- Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells. Horikawa, Y., Shatos, M.A., Hodges, R.R., Zoukhri, D., Rios, J.D., Chang, E.L., Bernardino, C.R., Rubin, P.A., Dartt, D.A. Invest. Ophthalmol. Vis. Sci. (2003)
- Presynaptic dopamine D2 and muscarine M3 receptors inhibit excitatory and inhibitory transmission to rat subthalamic neurones in vitro. Shen, K.Z., Johnson, S.W. J. Physiol. (Lond.) (2000)
- Histamine innervation and activation of septohippocampal GABAergic neurones: involvement of local ACh release. Xu, C., Michelsen, K.A., Wu, M., Morozova, E., Panula, P., Alreja, M. J. Physiol. (Lond.) (2004)
- Change in muscarinic modulation of transmitter release in the rat urinary bladder after spinal cord injury. Somogyi, G.T., Zernova, G.V., Yoshiyama, M., Rocha, J.N., Smith, C.P., de Groat, W.C. Neurochem. Int. (2003)
- Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice. Koga, K., Honda, K., Ando, S., Harasawa, I., Kamiya, H.O., Takano, Y. Eur. J. Pharmacol. (2004)
- Extracellular signal regulated protein kinase and c-jun N-terminal kinase are involved in ml muscarinic receptor-enhanced interleukin-2 production pathway in Jurkat cells. Fujino, H., Uehara, T., Murayama, T., Okuma, Y., Ariga, H., Nomura, Y. Biol. Pharm. Bull. (2000)
- The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder. Ehlert, F.J., Griffin, M.T., Abe, D.M., Vo, T.H., Taketo, M.M., Manabe, T., Matsui, M. J. Pharmacol. Exp. Ther. (2005)
- Expression of muscarinic M3-receptors coupled to inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. Harriss, D.R., Marsh, K.A., Birmingham, A.T., Hill, S.J. J. Urol. (1995)
- Muscarinic control of phase III contractions and motilin release in dogs. Yamada, T., Mizumoto, A., Satoh, M., Haga, N., Itoh, Z. Peptides (1997)
- Long vasodilator reflexes projecting through the myenteric plexus in guinea-pig ileum. Reed, D.E., Vanner, S.J. J. Physiol. (Lond.) (2003)
- Cardiovascular effects of carbachol microinjected into the bed nucleus of the stria terminalis of the rat brain. Alves, F.H., Crestani, C.C., Resstel, L.B., Corrêa, F.M. Brain Res. (2007)
- Vasocontractile muscarinic M1 receptors in cat cerebral arteries: pharmacological identification and detection of mRNA. Dauphin, F., Ting, V., Payette, P., Dennis, M., Hamel, E. Eur. J. Pharmacol. (1991)
- Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists. Gabelt, B.T., Kaufman, P.L. Exp. Eye Res. (1994)
- Effects of slaframine and 4-diphenylacetoxy-N-methylpiperidine methiodide (4DAMP) on pancreatic exocrine secretion in the bovine. Walker, J.A., Krehbiel, C.R., Harmon, D.L., St Jean, G., Croom, W.J., Hagler, W.M. Can. J. Physiol. Pharmacol. (1994)