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Gene Review:

Map2k7 - mitogen activated protein kinase kinase 7

Rattus norvegicus

Synonyms: Dual specificity mitogen-activated protein kinase kinase 7, JNK kinase 2, JNK-activating kinase 2, JNKK, JNKK 2, ...

Petrich, B.G. et al., Zhang, Q. et al., Li, C.H. et al., Trotter, L. et al.

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Disease relevance of Map2k7

To determine whether mitogen-activated protein kinase kinase 7 (MKK7) play a role in JNK activation in response to the stress of global cerebral ischemia, we tested the activation of such a kinase by using phospho-Ser and phospho-Thr antibodies [1].

High impact information on Map2k7

Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region [2].
Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons [3].
To investigate the specific role of JNK activation in the regulation of connexin in cardiomyocytes, an activated mutant of mitogen-activated protein kinase kinase 7 (mutant D), a JNK-specific upstream activator, was expressed in myocytes by adenovirus-mediated gene transfer [4].

References

Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats. Zhang, Q., Tian, H., Fu, X., Zhang, G. Life Sci. (2003) [Pubmed]
Activated mitogen-activated protein kinase kinase 7 redistributes to the cytosol and binds to Jun N-terminal kinase-interacting protein 1 involving oxidative stress during early reperfusion in rat hippocampal CA1 region. Li, C.H., Wang, R.M., Zhang, Q.G., Zhang, G.Y. J. Neurochem. (2005) [Pubmed]
Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons. Trotter, L., Panton, W., Hajimohamadreza, I., Petalidis, L., Ward, R., Fleming, Y., Armstrong, C.G., Cohen, P., Karran, E.H., Kinloch, R.A. Neurosci. Lett. (2002) [Pubmed]
c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Petrich, B.G., Gong, X., Lerner, D.L., Wang, X., Brown, J.H., Saffitz, J.E., Wang, Y. Circ. Res. (2002) [Pubmed]

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