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Gene Review: 

Map2k7  -  mitogen-activated protein kinase kinase 7

Mus musculus

Synonyms: 5930412N11Rik, Dual specificity mitogen-activated protein kinase kinase 7, JNK kinase 2, JNK-activating kinase 2, JNKK 2, ...
 
 
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Disease relevance of Map2k7

  • In vivo studies show that both JNKK1/MKK4 and MKK7 suppress the formation of overt metastases by inhibiting the ability of disseminated cells to colonize the lung (secondary site) [1].
 

High impact information on Map2k7

  • Loss of MKK7 in thymocytes and mature B cells results in hyperproliferation in response to growth factor and antigen receptor stimulation and increased thymic cellularity [2].
  • These results indicate that the MKK7-regulated stress signaling pathway can function as negative regulator of cell growth in multiple hematopoietic lineages [2].
  • MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence [3].
  • Here we show that genetic inactivation of the stress signalling kinase, MKK7, a direct activator of JNKs in mice, results in embryonic lethality and impaired proliferation of hepatocytes [3].
  • Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7 [1].
 

Biological context of Map2k7

 

Anatomical context of Map2k7

 

Other interactions of Map2k7

  • Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand [7].
  • More important, a peptide containing the Tat protein transduction sequence (Tat-GluR6-9c) perturbed the assembly of the GluR6-PSD95-MLK3 signaling module and suppressed the activation of MLK3, MKK7, and JNK [8].
 

Analytical, diagnostic and therapeutic context of Map2k7

  • A cis-trans test via allele specific expression analysis of the MKK7 gene in F1 hybrids between domesticus and musculus shows that the expression change is mainly caused by a mutation located in cis [9].
  • To examine the physiological role of MKK7 in hematopoietic cells, we used a gene targeting strategy to mutate MKK7 in murine T and B cells and non-lymphoid mast cells [2].

References

  1. Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7. Vander Griend, D.J., Kocherginsky, M., Hickson, J.A., Stadler, W.M., Lin, A., Rinker-Schaeffer, C.W. Cancer Res. (2005) [Pubmed]
  2. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. Sasaki, T., Wada, T., Kishimoto, H., Irie-Sasaki, J., Matsumoto, G., Goto, T., Yao, Z., Wakeham, A., Mak, T.W., Suzuki, A., Cho, S.K., Zuniga-Pflucker, J.C., Oliveira-dos-Santos, A.J., Katada, T., Nishina, H., Penninger, J.M. J. Exp. Med. (2001) [Pubmed]
  3. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Wada, T., Joza, N., Cheng, H.Y., Sasaki, T., Kozieradzki, I., Bachmaier, K., Katada, T., Schreiber, M., Wagner, E.F., Nishina, H., Penninger, J.M. Nat. Cell Biol. (2004) [Pubmed]
  4. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. Kaiser, R.A., Liang, Q., Bueno, O., Huang, Y., Lackey, T., Klevitsky, R., Hewett, T.E., Molkentin, J.D. J. Biol. Chem. (2005) [Pubmed]
  5. Stress kinase MKK7: savior of cell cycle arrest and cellular senescence. Wada, T., Penninger, J.M. Cell Cycle (2004) [Pubmed]
  6. Requirement of MKK4 and MKK7 for CdCl2- or HgCl2-induced activation of c-Jun NH2-terminal kinase in mouse embryonic stem cells. Matsuoka, M., Igisu, H., Nakagawa, K., Katada, T., Nishina, H. Toxicol. Lett. (2004) [Pubmed]
  7. Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand. Yamamoto, A., Miyazaki, T., Kadono, Y., Takayanagi, H., Miura, T., Nishina, H., Katada, T., Wakabayashi, K., Oda, H., Nakamura, K., Tanaka, S. J. Bone Miner. Res. (2002) [Pubmed]
  8. Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathways. Liu, X.M., Pei, D.S., Guan, Q.H., Sun, Y.F., Wang, X.T., Zhang, Q.X., Zhang, G.Y. J. Biol. Chem. (2006) [Pubmed]
  9. A change of expression in the conserved signaling gene MKK7 is associated with a selective sweep in the western house mouse Mus musculus domesticus. Harr, B., Voolstra, C., Heinen, T.J., Baines, J.F., Rottscheidt, R., Ihle, S., Müller, W., Bonhomme, F., Tautz, D. J. Evol. Biol. (2006) [Pubmed]
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