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Gene Review:

resD - site-specific recombinase

Escherichia coli

Crellin, P.K. et al., Camilli, A. et al., Blake, D.G. et al., Parsons, R.L. et al., Aberg, A. et al., et al.

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Disease relevance of resD

The site-specific recombinase (FLP) encoded by the yeast plasmid 2 micron circle belongs to the integrase (of phage lambda) family of recombinases [1].
(p)ppGpp regulates type 1 fimbriation of Escherichia coli by modulating the expression of the site-specific recombinase FimB [2].
The resolvase/invertase domain of the site-specific recombinase TnpX is functional and recognizes a target sequence that resembles the junction of the circular form of the Clostridium perfringens transposon Tn4451 [3].

High impact information on resD

The catalytic domain of lambda site-specific recombinase [4].
To extend the utility of the reporter gene fusion approach to such studies, we have constructed a gene expression reporter cassette that permits the generation of transcriptional fusions to tnpR encoding resolvase, a site-specific recombinase of the transposable element gamma delta [5].
Our study of how a site-specific recombinase recognizes an inverted-repeat binding site indicates that such sequence asymmetry can be functionally important [6].

References

Step-arrest mutants of FLP recombinase: implications for the catalytic mechanism of DNA recombination. Parsons, R.L., Prasad, P.V., Harshey, R.M., Jayaram, M. Mol. Cell. Biol. (1988) [Pubmed]
(p)ppGpp regulates type 1 fimbriation of Escherichia coli by modulating the expression of the site-specific recombinase FimB. Aberg, A., Shingler, V., Balsalobre, C. Mol. Microbiol. (2006) [Pubmed]
The resolvase/invertase domain of the site-specific recombinase TnpX is functional and recognizes a target sequence that resembles the junction of the circular form of the Clostridium perfringens transposon Tn4451. Crellin, P.K., Rood, J.I. J. Bacteriol. (1997) [Pubmed]
The catalytic domain of lambda site-specific recombinase. Tirumalai, R.S., Healey, E., Landy, A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Use of genetic recombination as a reporter of gene expression. Camilli, A., Beattie, D.T., Mekalanos, J.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
Cooperative binding of Tn3 resolvase monomers to a functionally asymmetric binding site. Blake, D.G., Boocock, M.R., Sherratt, D.J., Stark, W.M. Curr. Biol. (1995) [Pubmed]

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