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Gene Review: 

Tb10.61.2880  -  aconitase

Trypanosoma brucei brucei strain 927/4 GUTat10.1

 
 
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High impact information on Tb10.61.2880

  • Importantly, there was absolutely no difference in the metabolic products released by wild type and aconitase knockout parasites, and both were for survival strictly dependent on respiration via the mitochondrial electron transport chain [1].
  • No differences in intracellular levels of glycolytic and Krebs cycle intermediates were found in procyclic wild type and mutant cells, except for citrate that accumulated up to 90-fold in the mutants, confirming the absence of aconitase activity [1].
  • This was unexpected since an arginine conserved in the aconitase protein family and crucial for substrate positioning in the catalytic center and for activity of pig mitochondrial aconitase (Zheng, L., Kennedy, M. C., Beinert, H., and Zalkin, H. (1992) J. Biol. Chem. 267, 7895-7903) is substituted by leucine in the TbACO sequence [2].
  • A developmentally regulated aconitase related to iron-regulatory protein-1 is localized in the cytoplasm and in the mitochondrion of Trypanosoma brucei [2].

References

  1. Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation. van Weelden, S.W., Fast, B., Vogt, A., van der Meer, P., Saas, J., van Hellemond, J.J., Tielens, A.G., Boshart, M. J. Biol. Chem. (2003) [Pubmed]
  2. A developmentally regulated aconitase related to iron-regulatory protein-1 is localized in the cytoplasm and in the mitochondrion of Trypanosoma brucei. Saas, J., Ziegelbauer, K., von Haeseler, A., Fast, B., Boshart, M. J. Biol. Chem. (2000) [Pubmed]
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