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Gene Review: 

Cdk5  -  Cyclin-dependent kinase 5

Drosophila melanogaster

Synonyms: CDK5, CG8203, Cell division protein kinase 5, Cyclin-dependent kinase 5 homolog, DmCdk5, ...
 
 
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High impact information on Cdk5

  • Abundant expression already at the start of embryogenesis and long before neuron differentiation was also observed in the case of cdk5 protein, which has been described as predominantly neuron specific in mice [1].
  • The putative amino acid sequence for Drosophila Cdk5 predicts a protein with a mass of approximately 32 kDa that is 77% identical to its mammalian counter-parts [2].
  • Drosophila Cdk5 gene is located in polytene chromosomal region 52BC of the right arm of chromosome 2 [2].
  • Cyclin-dependent kinase 5 activator (Cdk5alpha) is an activator of Cdk5 kinase activity and its expression is restricted to neurons [3].
  • Thus, Cdc2 and Cdk5 kinases are the potential regulators of the function of Canoe in morphogenesis [4].

References

  1. Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase. Sauer, K., Weigmann, K., Sigrist, S., Lehner, C.F. Mol. Biol. Cell (1996) [Pubmed]
  2. Cloning and characterization of the Drosophila melanogaster CDK5 homolog. Hellmich, M.R., Kennison, J.A., Hampton, L.L., Battey, J.F. FEBS Lett. (1994) [Pubmed]
  3. A Drosophila CDK5alpha-like molecule and its possible role in response to O(2) deprivation. Ma, E., Haddad, G. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  4. Ras target protein canoe is a substrate for Cdc2 and Cdk5 kinases. Takahashi, K., Hamada, N., Yamamoto, D. Arch. Insect Biochem. Physiol. (2002) [Pubmed]
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