Gene Review:
CDK5 - cyclin-dependent kinase 5
Homo sapiens
Synonyms:
CDKN5, Cell division protein kinase 5, Cyclin-dependent-like kinase 5, PSSALRE, Serine/threonine-protein kinase PSSALRE, ...
Nikolic,
Ermini,
Fraser,
Sato,
Wu,
Tandon,
Yu,
Kríz,
St George-Hyslop,
Salinas,
Nakano,
Garnier,
Kelly,
Kang,
Rogaeva,
Bertelli,
Tate,
Thunnissen,
Nakao,
Pettit,
Meijer,
Wang,
Helal,
Nakano,
Hasegawa,
Tsuboi,
Westaway,
Cooper,
Toti,
Mannucci,
Chen,
Cleverley,
Otyepka,
Lucas,
Kimura,
Okumura,
Kominami,
Occhini,
Regoli,
Chishti,
Fonzi,
Walter,
Kim,
Sanner,
Adam,
Kupchinsky,
Nakamura,
Akiguchi,
Peterson,
Tsai,
Ahlijanian,
Bártová,
Ogawa,
White,
Kawashima,
Biernat,
Gant,
Davies,
Menniti,
Satoi,
Kawarai,
Mandelkow,
Ishidoh,
Koca,
- Mechanism of CDK5/p25 binding by CDK inhibitors. Mapelli, M., Massimiliano, L., Crovace, C., Seeliger, M.A., Tsai, L.H., Meijer, L., Musacchio, A. J. Med. Chem. (2005)
- CDK5 regulates cell-cell and cell-matrix adhesion in human keratinocytes. Nakano, N., Nakao, A., Ishidoh, K., Tsuboi, R., Kominami, E., Okumura, K., Ogawa, H. Br. J. Dermatol. (2005)
- Involvement of Cdk5/p25 in digoxin-triggered prostate cancer cell apoptosis. Lin, H., Juang, J.L., Wang, P.S. J. Biol. Chem. (2004)
- Aberrant expression of cyclin-dependent kinase 5 in inclusion body myositis. Nakano, S., Akiguchi, I., Nakamura, S., Satoi, H., Kawashima, S., Kimura, J. Neurology (1999)
- Cyclin-dependent kinase 5 and mitogen-activated protein kinase in glial cytoplasmic inclusions in multiple system atrophy. Nakamura, S., Kawamoto, Y., Nakano, S., Akiguchi, I., Kimura, J. J. Neuropathol. Exp. Neurol. (1998)
- Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant k-ras. Eggers, J.P., Grandgenett, P.M., Collisson, E.C., Lewallen, M.E., Tremayne, J., Singh, P.K., Swanson, B.J., Andersen, J.M., Caffrey, T.C., High, R.R., Ouellette, M., Hollingsworth, M.A. Clin. Cancer Res. (2011)
- Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau. Hashiguchi, M., Saito, T., Hisanaga, S., Hashiguchi, T. J. Biol. Chem. (2002)
- Downregulation of neuronal cdk5/p35 in opioid addicts and opiate-treated rats: relation to neurofilament phosphorylation. Ferrer-Alcón, M., La Harpe, R., Guimón, J., García-Sevilla, J.A. Neuropsychopharmacology (2003)
- A decade of CDK5. Dhavan, R., Tsai, L.H. Nat. Rev. Mol. Cell Biol. (2001)
- Neuroadaptations of Cdk5 in cholinergic interneurons of the nucleus accumbens and prefrontal cortex of inbred alcohol-preferring rats following voluntary alcohol drinking. Camp, M.C., Mayfield, R.D., McCracken, M., McCracken, L., Alcantara, A.A. Alcohol. Clin. Exp. Res. (2006)
- 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Toyo-oka, K., Shionoya, A., Gambello, M.J., Cardoso, C., Leventer, R., Ward, H.L., Ayala, R., Tsai, L.H., Dobyns, W., Ledbetter, D., Hirotsune, S., Wynshaw-Boris, A. Nat. Genet. (2003)
- Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Patrick, G.N., Zukerberg, L., Nikolic, M., de la Monte, S., Dikkes, P., Tsai, L.H. Nature (1999)
- The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity. Nikolic, M., Chou, M.M., Lu, W., Mayer, B.J., Tsai, L.H. Nature (1998)
- Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Meijer, L., Thunnissen, A.M., White, A.W., Garnier, M., Nikolic, M., Tsai, L.H., Walter, J., Cleverley, K.E., Salinas, P.C., Wu, Y.Z., Biernat, J., Mandelkow, E.M., Kim, S.H., Pettit, G.R. Chem. Biol. (2000)
- Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells. Lee, J.H., Kim, K.T. J. Neurochem. (2004)
- CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. Kim, E., Chen, F., Wang, C.C., Harrison, L.E. Int. J. Oncol. (2006)
- Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease. Helal, C.J., Sanner, M.A., Cooper, C.B., Gant, T., Adam, M., Lucas, J.C., Kang, Z., Kupchinsky, S., Ahlijanian, M.K., Tate, B., Menniti, F.S., Kelly, K., Peterson, M. Bioorg. Med. Chem. Lett. (2004)
- Networking with proline-directed protein kinases implicated in tau phosphorylation. Pelech, S.L. Neurobiol. Aging (1995)
- Structure and regulation of the CDK5-p25(nck5a) complex. Tarricone, C., Dhavan, R., Peng, J., Areces, L.B., Tsai, L.H., Musacchio, A. Mol. Cell (2001)
- Identification of substrate binding site of cyclin-dependent kinase 5. Sharma, P., Steinbach, P.J., Sharma, M., Amin, N.D., Barchi, J.J., Pant, H.C. J. Biol. Chem. (1999)
- Cyclin-dependent kinase inhibitors: cancer killers to neuronal guardians. Monaco, E.A., Vallano, M.L. Current medicinal chemistry. (2003)
- Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction. Weishaupt, J.H., Kussmaul, L., Grötsch, P., Heckel, A., Rohde, G., Romig, H., Bähr, M., Gillardon, F. Mol. Cell. Neurosci. (2003)
- Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles. Tandon, A., Yu, H., Wang, L., Rogaeva, E., Sato, C., Chishti, M.A., Kawarai, T., Hasegawa, H., Chen, F., Davies, P., Fraser, P.E., Westaway, D., St George-Hyslop, P.H. J. Neurochem. (2003)
- Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells. Ubeda, M., Kemp, D.M., Habener, J.F. Endocrinology (2004)
- Nestin expression in adult and developing human kidney. Bertelli, E., Regoli, M., Fonzi, L., Occhini, R., Mannucci, S., Ermini, L., Toti, P. J. Histochem. Cytochem. (2007)
- Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics. Otyepka, M., Bártová, I., Kríz, Z., Koca, J. J. Biol. Chem. (2006)
- Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist. Wang, Y., Xie, W.Y., He, Y., Wang, M., Yang, Y.R., Zhang, Y., Yin, D.M., Jordan-Sciutto, K.L., Han, J.S., Wang, Y. Exp. Neurol. (2006)
- Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide. Kesavapany, S., Li, B.S., Amin, N., Zheng, Y.L., Grant, P., Pant, H.C. Biochim. Biophys. Acta (2004)
- Increase of cdk5 is related to neurofibrillary pathology in progressive supranuclear palsy. Borghi, R., Giliberto, L., Assini, A., Delacourte, A., Perry, G., Smith, M.A., Strocchi, P., Zaccheo, D., Tabaton, M. Neurology (2002)
- DARPP-32: an integrator of neurotransmission. Svenningsson, P., Nishi, A., Fisone, G., Girault, J.A., Nairn, A.C., Greengard, P. Annu. Rev. Pharmacol. Toxicol. (2004)
- Amphiphysin 1 binds the cyclin-dependent kinase (cdk) 5 regulatory subunit p35 and is phosphorylated by cdk5 and cdc2. Floyd, S.R., Porro, E.B., Slepnev, V.I., Ochoa, G.C., Tsai, L.H., De Camilli, P. J. Biol. Chem. (2001)
- CDK-5-mediated neurofilament phosphorylation in SHSY5Y human neuroblastoma cells. Sharma, M., Sharma, P., Pant, H.C. J. Neurochem. (1999)
- p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease. Nakamura, S., Kawamoto, Y., Nakano, S., Akiguchi, I., Kimura, J. Acta Neuropathol. (1997)
- Cdk5/p35 and Rho-kinase mediate ephrin-A5-induced signaling in retinal ganglion cells. Cheng, Q., Sasaki, Y., Shoji, M., Sugiyama, Y., Tanaka, H., Nakayama, T., Mizuki, N., Nakamura, F., Takei, K., Goshima, Y. Mol. Cell. Neurosci. (2003)
- Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2. Wang, C.X., Song, J.H., Song, D.K., Yong, V.W., Shuaib, A., Hao, C. Cell Death Differ. (2006)
- Cdk5 Regulates STAT3 Activation and Cell Proliferation in Medullary Thyroid Carcinoma Cells. Lin, H., Chen, M.C., Chiu, C.Y., Song, Y.M., Lin, S.Y. J. Biol. Chem. (2007)
- ATP-site directed inhibitors of cyclin-dependent kinases. Gray, N., Détivaud, L., Doerig, C., Meijer, L. Current medicinal chemistry. (1999)
- Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs. Johnson, K., Liu, L., Majdzadeh, N., Chavez, C., Chin, P.C., Morrison, B., Wang, L., Park, J., Chugh, P., Chen, H.M., D'Mello, S.R. J. Neurochem. (2005)
- Cdk5 and munc-18/p67 co-localization in early stage neurofibrillary tangles-bearing neurons in Alzheimer type dementia brains. Takahashi, M., Iseki, E., Kosaka, K. J. Neurol. Sci. (2000)
- Involvement of cyclin-dependent kinases in axotomy-induced retinal ganglion cell death. Lefèvre, K., Clarke, P.G., Danthe, E.E., Castagné, V. J. Comp. Neurol. (2002)
- Cdk5 regulates the organization of Nestin and its association with p35. Sahlgren, C.M., Mikhailov, A., Vaittinen, S., Pallari, H.M., Kalimo, H., Pant, H.C., Eriksson, J.E. Mol. Cell. Biol. (2003)
- Involvement of cyclin D1-cdk5 overexpression and MCM3 cleavage in bax-associated spontaneous apoptosis and differentiation in an A253 human head and neck carcinoma xenograft model. Yin, M.B., Tóth, K., Cao, S., Guo, B., Frank, C., Slocum, H.K., Rustum, Y.M. Int. J. Cancer (1999)
- Structure, function, and regulation of neuronal Cdc2-like protein kinase. Lew, J., Qi, Z., Huang, Q.Q., Paudel, H., Matsuura, I., Matsushita, M., Zhu, X., Wang, J.H. Neurobiol. Aging (1995)