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Gene Review

fab1  -  CG6355 gene product from transcript CG6355-RA

Drosophila melanogaster

Synonyms: CG6355, Dmel\CG6355, EG:52C10.5, Fab1, PIKfyve, ...
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High impact information on CG6355


Associations of CG6355 with chemical compounds

  • Genetic and ultrastructural analysis showed that subunits of endosomal sorting complex required for transport (ESCRT)-I, -II and -III, as well as their regulatory ATPase Vps4 and the endosomal PtdIns(3)P 5-kinase Fab1, all are required for autophagy [2].


  1. skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release. Hassan, B.A., Prokopenko, S.N., Breuer, S., Zhang, B., Paululat, A., Bellen, H.J. Genetics (1998) [Pubmed]
  2. ESCRTs and Fab1 regulate distinct steps of autophagy. Rusten, T.E., Vaccari, T., Lindmo, K., Rodahl, L.M., Nezis, I.P., Sem-Jacobsen, C., Wendler, F., Vincent, J.P., Brech, A., Bilder, D., Stenmark, H. Curr. Biol. (2007) [Pubmed]
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