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Gene Review:

fab1 - CG6355 gene product from transcript CG6355-RA

Drosophila melanogaster

Synonyms: CG6355, Dmel\CG6355, EG:52C10.5, Fab1, PIKfyve, ...

Hassan, B.A. et al., Rusten, T.E. et al.

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High impact information on CG6355

We have cloned and generated mutations in a Drosophila PIP5K type I (skittles) [1].
An important branching point in the pathway is the phosphorylation of phosphatidylinositol 4-phosphate by the phosphatidylinositol 4-phosphate 5-kinase (PIP5K) to generate the second messenger phosphatidylinositol 4,5-bis-phosphate (PIP2) [1].
PIP5K and PIP2 have been implicated in signal transduction, cytoskeletal regulation, DNA synthesis, and vesicular trafficking [1].

Associations of CG6355 with chemical compounds

Genetic and ultrastructural analysis showed that subunits of endosomal sorting complex required for transport (ESCRT)-I, -II and -III, as well as their regulatory ATPase Vps4 and the endosomal PtdIns(3)P 5-kinase Fab1, all are required for autophagy [2].

References

skittles, a Drosophila phosphatidylinositol 4-phosphate 5-kinase, is required for cell viability, germline development and bristle morphology, but not for neurotransmitter release. Hassan, B.A., Prokopenko, S.N., Breuer, S., Zhang, B., Paululat, A., Bellen, H.J. Genetics (1998) [Pubmed]
ESCRTs and Fab1 regulate distinct steps of autophagy. Rusten, T.E., Vaccari, T., Lindmo, K., Rodahl, L.M., Nezis, I.P., Sem-Jacobsen, C., Wendler, F., Vincent, J.P., Brech, A., Bilder, D., Stenmark, H. Curr. Biol. (2007) [Pubmed]

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AgaP_AGAP005216	Anopheles gambiae str. PEST
PIKFYVE	Bos taurus
PIKFYVE	Canis lupus familiaris
pikfyve	Danio rerio
PIKFYVE	Gallus gallus
PIKFYVE	Homo sapiens
PIKFYVE	Macaca mulatta
Pikfyve	Mus musculus
PIKFYVE	Pan troglodytes
Pikfyve	Rattus norvegicus

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