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Gene Review

FK506-bp2  -  FK506-binding protein 2

Drosophila melanogaster

Synonyms: 11001, 12 kDa FK506-binding protein, 143729_at, CG11001, Dmel\CG11001, ...
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High impact information on FK506-bp2

  • FKBP12 binds to ligand-free TGF beta type I receptor, from which it is released upon a ligand-induced, type II receptor mediated phosphorylation of the type I receptor [1].
  • The immunophilins cyclophilin and FK506 binding protein (FKBP) are small, predominantly soluble proteins that bind the immunosuppressant drugs cyclosporin A and FK506, respectively, with high affinity, and which seem to mediate their pharmacological actions [2].
  • Antisense experiments revealed that the so observed regulation of the FK506-binding protein, FKBP38, plays a role in TSC gene-dependent cell size regulation [3].
  • The shut-down gene of Drosophila melanogaster encodes a novel FK506-binding protein essential for the formation of germline cysts during oogenesis [4].
  • A Drosophila cDNA encoding a structural homolog of mammalian FKBP59 (also identified as FKBP52), a member of the FK506-binding protein (FKBP) class of immunophilins, was isolated [5].

Biological context of FK506-bp2

  • The third group of PPIases encoded in the genome comprises two proteins (hPin1 and hParv14) where hPin1 is an important PPIase for cell cycle [6].
  • The predicted amino acid sequence of this cDNA shows that the dFKBP59 protein contains one highly conserved FKBP12-like domain followed by two others with less conservation [5].

Analytical, diagnostic and therapeutic context of FK506-bp2


  1. The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors. Wang, T., Li, B.Y., Danielson, P.D., Shah, P.C., Rockwell, S., Lechleider, R.J., Martin, J., Manganaro, T., Donahoe, P.K. Cell (1996) [Pubmed]
  2. High brain densities of the immunophilin FKBP colocalized with calcineurin. Steiner, J.P., Dawson, T.M., Fotuhi, M., Glatt, C.E., Snowman, A.M., Cohen, N., Snyder, S.H. Nature (1992) [Pubmed]
  3. Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38. Rosner, M., Hofer, K., Kubista, M., Hengstschläger, M. Oncogene (2003) [Pubmed]
  4. The shut-down gene of Drosophila melanogaster encodes a novel FK506-binding protein essential for the formation of germline cysts during oogenesis. Munn, K., Steward, R. Genetics (2000) [Pubmed]
  5. Molecular cloning and embryonic expression of dFKBP59, a novel Drosophila FK506-binding protein. Zaffran, S. Gene (2000) [Pubmed]
  6. Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions. Galat, A. Current topics in medicinal chemistry. (2003) [Pubmed]
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