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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

h3  -  histone H3

Strongylocentrotus purpuratus

 
 
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High impact information on H3

  • The DNA sequence of sea urchin (S. purpuratus) H2A, H2B and H3 histone coding and spacer regions [1].
  • Deletion analysis of the upstream promoter region of the H3 gene revealed several regions that are involved in both positive and negative control [2].
  • The TATA box and CCAAT sequences are all that is required for expression of low levels of H3 transcripts with the proper temporal pattern [2].
  • The recombinant chicken DNA library was screened for histone genes by using pSp17, a recombinant sea urchin DNA probe containing the H2a and H3 genes of Strongylocentrotus purpuratus [3].
  • The organization of these genes is similar to the divergently transcribed H3-H4 gene pairs of Lytechinus pictus [4].
 

Biological context of H3

  • Whole genome Southern analysis indicates that most late H3 and H4 genes are organized as pairs in both sea urchin genomes [4].
  • A gene pair coding for histones H3 and H4 expressed during late embryonic development has been cloned from the S. purpuratus genome [4].
 

Other interactions of H3

  • It is known that there are two histone genes, H3 and H2A, on pSp17 [5].

References

  1. The DNA sequence of sea urchin (S. purpuratus) H2A, H2B and H3 histone coding and spacer regions. Sures, I., Lowry, J., Kedes, L.H. Cell (1978) [Pubmed]
  2. Developmental control of promoter-specific factors responsible for the embryonic activation and inactivation of the sea urchin early histone H3 gene. DiLiberto, M., Lai, Z.C., Fei, H., Childs, G. Genes Dev. (1989) [Pubmed]
  3. Histone genes are clustered but not tandemly repeated in the chicken genome. Engel, J.D., Dodgson, J.B. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  4. Sequence, organization and expression of late embryonic H3 and H4 histone genes from the sea urchin, Strongylocentrotus purpuratus. Kaumeyer, J.F., Weinberg, E.S. Nucleic Acids Res. (1986) [Pubmed]
  5. Positions of sea urchin (Strongylocentrotus purpuratus) histone genes relative to restriction endonuclease sites on the chimeric plasmids pSp2 and pSp17. Holmes, D.S., Cohn, R.H., Kedes, L.H., Davidson, N. Biochemistry (1977) [Pubmed]
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