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Gene Review: 

il1b  -  interleukin 1, beta

Xenopus laevis

Synonyms: IL-1, IL-1B, il1b-A
 
 
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High impact information on il1b-A

  • These and other data suggest that IL-1beta and its type 1 receptor may be involved in the maintenance of cell survival rather than induction of neuronal death [1].
  • The cytokine interleukin-1 beta (IL-1beta) is an evolutionarily conserved molecule that was originally identified in the immune system [1].
  • Active IL-1beta is produced by interleukin-converting enzyme (ICE), a caspase thought to be involved in the induction of apoptosis [1].
  • IL-1beta and IL-1 type 1 receptor proteins are colocalized in specific midbrain and hindbrain reticular cells, including Mauthner's neuron; specific cells in the trigeminal (fifth), lateral line (seventh), and vestibular (eighth) cranial ganglia; oculomotor neurons; and the primordial Purkinje cells of the lateral cerebellar auricle [1].

References

  1. Interleukin-1beta and its type 1 receptor are expressed in developing neural circuits in the frog, Xenopus laevis. Jelaso, A.M., Acevedo, S., Dang, T., Lepere, A., Ide, C.F. J. Comp. Neurol. (1998) [Pubmed]
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