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Gene Review

UCP3  -  uncoupling protein 3 (mitochondrial,...

Gallus gallus

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Disease relevance of UCP3

  • Since mammalian UCP 2 and UCP 3 also appear to have functions associated with energy and substrate partitioning and body weight regulation, the purpose of this study was to further characterize chicken UCP under conditions of nutritional stress and/or leptin administration [1].

Psychiatry related information on UCP3

  • RESULTS: By quantitative PCR we demonstrated a positive correlation of Coup-TFII and Ucp3 mRNA expression in skeletal muscle and brown adipose tissue in response to food deprivation and cold exposure, respectively [2].

High impact information on UCP3


Anatomical context of UCP3

  • CONCLUSION: Transcriptional regulation of the Coup-TFII gene in response to starvation and cold exposure seems to be the regulatory mechanism of Ucp3 mRNA expression in brown adipose and skeletal muscle tissue determining the final appropriate rate of transcript synthesis [2].


  1. Expression of an uncoupling protein gene homolog in chickens. Evock-Clover, C.M., Poch, S.M., Richards, M.P., Ashwell, C.M., McMurtry, J.P. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2002) [Pubmed]
  2. Chicken ovalbumin upstream promoter transcription factor II regulates uncoupling protein 3 gene transcription in Phodopus sungorus. Fromme, T., Reichwald, K., Platzer, M., Li, X.S., Klingenspor, M. BMC Mol. Biol. (2007) [Pubmed]
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