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Gene Review:

RUNX2 - runt-related transcription factor 2

Gallus gallus

Li, T.F. et al., Rath, N.C. et al., Buxton, P.G. et al.

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High impact information on RUNX2

Analysis of gene expression revealed that secondary chondrocytes formed coincident with Sox9 upregulation from a precursor population expressing Cbfa1/Runx2: a reversal of the normal sequence [1].
We have previously reported cooperative effects between BMP and RA downstream signaling involving Smad proteins and Runx2 [2].
In the present study, we investigated the effect of PTHrP on Runx2 expression in chick upper sternal chondrocytes (USCs) [2].
Runx2 activity can be modulated in several ways, including direct stimulation of gene expression, post-translational modification, and protein-protein interactions [2].
Thiram appeared to have no effect on the expression of type X collagen, transglutaminase, RUNX2, or matrix metalloproteinase-2 (MMP) genes suggesting that it did not alter the maturation potential of chondrocytes [3].

References

Secondary chondrocyte-derived Ihh stimulates proliferation of periosteal cells during chick development. Buxton, P.G., Hall, B., Archer, C.W., Francis-West, P. Development (2003) [Pubmed]
Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Li, T.F., Dong, Y., Ionescu, A.M., Rosier, R.N., Zuscik, M.J., Schwarz, E.M., O'Keefe, R.J., Drissi, H. Exp. Cell Res. (2004) [Pubmed]
Changes in the tibial growth plates of chickens with thiram-induced dyschondroplasia. Rath, N.C., Richards, M.P., Huff, W.E., Huff, G.R., Balog, J.M. J. Comp. Pathol. (2005) [Pubmed]

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RUNX2	Bos taurus
runx2a	Danio rerio
RUNX2	Homo sapiens
RUNX2	Macaca mulatta
Runx2	Mus musculus
RUNX2	Pan troglodytes
Runx2	Rattus norvegicus
runx2	Xenopus (Silurana) tropicalis

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