Gene Review:
Runx2 - runt-related transcription factor 2
Rattus norvegicus
Synonyms:
CBF-alpha-1, Cbfa1, Core-binding factor subunit alpha-1, OSF-2, Osf2, ...
- Runt domain factor (Runx)-dependent effects on CCAAT/ enhancer-binding protein delta expression and activity in osteoblasts. McCarthy, T.L., Ji, C., Chen, Y., Kim, K.K., Imagawa, M., Ito, Y., Centrella, M. J. Biol. Chem. (2000)
- Altered Cbfa1 expression and biomineralization in an osteosarcoma cell line. Perinpanayagam, H., Schneider, G., Holtman, K., Zaharias, R., Stanford, C. J. Orthop. Res. (2004)
- Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Paredes, R., Arriagada, G., Cruzat, F., Villagra, A., Olate, J., Zaidi, K., van Wijnen, A., Lian, J.B., Stein, G.S., Stein, J.L., Montecino, M. Mol. Cell. Biol. (2004)
- Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Sierra, J., Villagra, A., Paredes, R., Cruzat, F., Gutierrez, S., Javed, A., Arriagada, G., Olate, J., Imschenetzky, M., Van Wijnen, A.J., Lian, J.B., Stein, G.S., Stein, J.L., Montecino, M. Mol. Cell. Biol. (2003)
- Runx2 regulates endochondral ossification in condyle during mandibular advancement. Tang, G.H., Rabie, A.B. J. Dent. Res. (2005)
- Characterization of a novel KRAB/C2H2 zinc finger transcription factor involved in bone development. Jheon, A.H., Ganss, B., Cheifetz, S., Sodek, J. J. Biol. Chem. (2001)
- Immunohistochemical Localization of {alpha}-Smooth Muscle Actin During Rat Molar Tooth Development. Hosoya, A., Nakamura, H., Ninomiya, T., Yoshiba, K., Yoshiba, N., Nakaya, H., Wakitani, S., Yamada, H., Kasahara, E., Ozawa, H. J. Histochem. Cytochem. (2006)
- Exogenous Runx2 expression enhances in vitro osteoblastic differentiation and mineralization in primary bone marrow stromal cells. Byers, B.A., García, A.J. Tissue engineering. (2004)
- JNK/ERK-AP-1/Runx2 induction "paves the way" to cartilage load-ignited chondroblastic differentiation. Papachristou, D.J., Pirttiniemi, P., Kantomaa, T., Papavassiliou, A.G., Basdra, E.K. Histochem. Cell Biol. (2005)
- Runx2 integrates estrogen activity in osteoblasts. McCarthy, T.L., Chang, W.Z., Liu, Y., Centrella, M. J. Biol. Chem. (2003)
- Ghrelin directly regulates bone formation. Fukushima, N., Hanada, R., Teranishi, H., Fukue, Y., Tachibana, T., Ishikawa, H., Takeda, S., Takeuchi, Y., Fukumoto, S., Kangawa, K., Nagata, K., Kojima, M. J. Bone Miner. Res. (2005)
- The Runx2 transcription factor plays a key role in the 1alpha,25-dihydroxy Vitamin D3-dependent upregulation of the rat osteocalcin (OC) gene expression in osteoblastic cells. Paredes, R., Arriagada, G., Cruzat, F., Olate, J., Van Wijnen, A., Lian, J., Stein, G., Stein, J., Montecino, M. J. Steroid Biochem. Mol. Biol. (2004)
- Control and counter-control of TGF-beta activity through FAST and Runx (CBFa) transcriptional elements in osteoblasts. Ji, C., Eickelberg, O., McCarthy, T.L., Centrella, M. Endocrinology (2001)
- Bone morphogenetic protein-2 suppresses collagenase-3 promoter activity in osteoblasts through a runt domain factor 2 binding site. Varghese, S., Rydziel, S., Canalis, E. J. Cell. Physiol. (2005)
- Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2. Selvamurugan, N., Kwok, S., Alliston, T., Reiss, M., Partridge, N.C. J. Biol. Chem. (2004)
- Transforming growth factor beta2 inhibits adipocyte differentiation induced by skeletal unloading in rat bone marrow stroma. Ahdjoudj, S., Lasmoles, F., Holy, X., Zerath, E., Marie, P.J. J. Bone Miner. Res. (2002)
- Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization. Byers, B.A., Guldberg, R.E., García, A.J. Tissue engineering. (2004)
- Strong and rapid induction of osteoblast differentiation by Cbfa1/Til-1 overexpression for bone regeneration. Kojima, H., Uemura, T. J. Biol. Chem. (2005)