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Gene Review

TYR  -  tyrosinase (oculocutaneous albinism IA)

Gallus gallus

 
 
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High impact information on TYR

  • We have identified two evolutionarily conserved regions within the 5' flanking sequence that may be functionally significant, as they contain regulatory elements previously reported to play a role in melanocyte-specific expression of TYR in mammals [1].
  • We have isolated and sequenced a genomic DNA sequence encoding chicken tyrosinase (TYR) that includes 2125 nt of 5' flanking sequence, the first exon and a part of the first intron [1].
  • Refined localization of the chicken KITLG, MGP and TYR genes on GGA1 by FISH mapping using BACs [2].
  • RESULTS: Molecular analysis of the chicken TYR gene has revealed a major structural difference (Restriction Fragment Length Polymorphism, RFLP) in the genomic DNA of the recessive white chicken [3].
 

Analytical, diagnostic and therapeutic context of TYR

  • A major size difference of 7.7 kb was found in intron 4 of the TYR gene by long-range PCR [3].

References

  1. Characteristic sequences in the promoter region of the chicken tyrosinase-encoding gene. Ferguson, C.A., Kidson, S.H. Gene (1996) [Pubmed]
  2. Refined localization of the chicken KITLG, MGP and TYR genes on GGA1 by FISH mapping using BACs. Sazanov, A.A., Sazanova, A.L., Tzareva, V.A., Kozyreva, A.A., Smirnov, A.F., Romanov, M.N., Price, J.A., Dodgson, J.B. Anim. Genet. (2004) [Pubmed]
  3. Complete association between a retroviral insertion in the tyrosinase gene and the recessive white mutation in chickens. Chang, C.M., Coville, J.L., Coquerelle, G., Gourichon, D., Oulmouden, A., Tixier-Boichard, M. BMC Genomics (2006) [Pubmed]
 
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