The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

tyr  -  tyrosinase

Danio rerio

Synonyms: SO:0000704, sandy, zgc:109705
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on tyr

  • We propose that retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry [1].
  • We found that a small molecule, (2-morpholinobutyl)-4-thiophenol (MoTP), specifically ablates zebrafish larval melanocytes or melanoblasts, and that this melanocytotoxicity is dependent on tyrosinase activity, which presumably converts MoTP to cytotoxic quinone species [2].
  • The tyrosinase inhibitor 1-phenyl-2-thiourea (PTU) is widely used in zebrafish research to suppress pigmentation in developing embryos/fry [3].
  • The Tol2 element is a transposable element in Oryzias latipes (the medaka fish) found in the tyrosinase gene locus of the tyrosinase-deficient mutant medaka fish and has been shown to be excised from the genome during medaka embryogenesis (Koga, A., Suzuki, M., Inagaki, H., Bessho, Y., Hori, H., 1996. Transposon element in fish. Nature 383, 30) [4].
  • We show that a region of 814 nt upstream from the translation start site of the zebrafish tyrosinase gene can drive expression in retinal pigmented epithelium in transiently transgenic zebrafish embryos but that its activity is not restricted to melanin-producing cells [5].

Biological context of tyr


  1. Retinal network adaptation to bright light requires tyrosinase. Page-McCaw, P.S., Chung, S.C., Muto, A., Roeser, T., Staub, W., Finger-Baier, K.C., Korenbrot, J.I., Baier, H. Nat. Neurosci. (2004) [Pubmed]
  2. Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes. Yang, C.T., Johnson, S.L. Development (2006) [Pubmed]
  3. Phenylthiourea as a weak activator of aryl hydrocarbon receptor inhibiting 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 transcription in zebrafish embryo. Wang, W.D., Wang, Y., Wen, H.J., Buhler, D.R., Hu, C.H. Biochem. Pharmacol. (2004) [Pubmed]
  4. Excision of the tol2 transposable element of the medaka fish, Oryzias latipes, in zebrafish, Danio rerio. Kawakami, K., Koga, A., Hori, H., Shima, A. Gene (1998) [Pubmed]
  5. Expression analysis of a tyrosinase promoter sequence in zebrafish. Camp, E., Badhwar, P., Mann, G.J., Lardelli, M. Pigment Cell Res. (2003) [Pubmed]
WikiGenes - Universities