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Gene Review

KITLG  -  KIT ligand

Gallus gallus

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High impact information on KITLG


Biological context of KITLG


Anatomical context of KITLG


Associations of KITLG with chemical compounds

  • Labeling studies with bromodeoxyuridine indicate that the neurons sustained by SCF are not differentiating from a dividing progenitor [8].
  • These cells, called SCF/TGF alpha progenitors, co-express the c-Kit receptor tyrosine kinase and c-ErbB, the avian receptor for epidermal growth factor and transforming growth factor (TGF) alpha, and they undergo continuous self renewal in response to TGF alpha and estradiol [4].
  • IFNgamma, TGFbeta(2), MGF and IL-1beta relative to beta-actin mRNA expression were analyzed in spleen cells stimulated with LPS [12].
  • Recombinant chicken stem cell factor (SCF) was produced in bacteria as a histidine-tagged protein (His delta SCF) and purified by affinity chromatography on an Ni(2+)-NTA agarose column [13].

Other interactions of KITLG


Analytical, diagnostic and therapeutic context of KITLG

  • Western blot analysis with the monoclonal antibody to the histidine tag identified SCF in the induced cell lysates and the purified sample [16].


  1. MLL-ENL cooperates with SCF to transform primary avian multipotent cells. Schulte, C.E., von Lindern, M., Steinlein, P., Beug, H., Wiedemann, L.M. EMBO J. (2002) [Pubmed]
  2. Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus. Lobmayr, L., Sauer, T., Killisch, I., Schranzhofer, M., Wilson, R.B., Ponka, P., Beug, H., Müllner, E.W. Blood (2002) [Pubmed]
  3. Stem cell factor stimulates chicken osteoclast activity in vitro. van't Hof, R.J., von Lindern, M., Nijweide, P.J., Beug, H. FASEB J. (1997) [Pubmed]
  4. Primary, self-renewing erythroid progenitors develop through activation of both tyrosine kinase and steroid hormone receptors. Steinlein, P., Wessely, O., Meyer, S., Deiner, E.M., Hayman, M.J., Beug, H. Curr. Biol. (1995) [Pubmed]
  5. Transformation of chicken bone marrow cells by the v-ski oncogene. Larsen, J., Meyer, S., Steinlein, P., Beug, H., Hayman, M.J. Oncogene (1993) [Pubmed]
  6. Transformation of erythroid progenitors by viral and cellular tyrosine kinases. Beug, H., Schroeder, C., Wessely, O., Deiner, E., Meyer, S., Ischenko, I.D., Hayman, M.J. Cell Growth Differ. (1995) [Pubmed]
  7. Expression of protein tyrosine kinases and stem cell factor in chicken blastodermal cells. Sasaki, E., Etches, R.J. Poult. Sci. (2001) [Pubmed]
  8. Stem cell factor is a neurotrophic factor for neural crest-derived chick sensory neurons. Carnahan, J.F., Patel, D.R., Miller, J.A. J. Neurosci. (1994) [Pubmed]
  9. Spi-1 and mutant p53 regulate different aspects of the proliferation and differentiation control of primary erythroid progenitors. Quang, C.T., Pironin, M., von Lindern, M., Beug, H., Ghysdael, J. Oncogene (1995) [Pubmed]
  10. The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation. Koritschoner, N.P., Bartůnĕk, P., Knespel, S., Blendinger, G., Zenke, M. Oncogene (1999) [Pubmed]
  11. Effects of cytokines from thymocytes and thymic stromal cells on chicken intrathymic T cell development. Mukamoto, M., Kodama, H., Baba, T. Vet. Immunol. Immunopathol. (1999) [Pubmed]
  12. Divergence of the inflammatory response in two types of chickens. Leshchinsky, T.V., Klasing, K.C. Dev. Comp. Immunol. (2001) [Pubmed]
  13. Avian stem cell factor (SCF): production and characterization of the recombinant His-tagged SCF of chicken and its neutralizing antibody. Bartůnĕk, P., Pichlíková, L., Stengl, G., Boehmelt, G., Martin, F.H., Beug, H., Dvorák, M., Zenke, M. Cytokine (1996) [Pubmed]
  14. Refined localization of the chicken KITLG, MGP and TYR genes on GGA1 by FISH mapping using BACs. Sazanov, A.A., Sazanova, A.L., Tzareva, V.A., Kozyreva, A.A., Smirnov, A.F., Romanov, M.N., Price, J.A., Dodgson, J.B. Anim. Genet. (2004) [Pubmed]
  15. Purification and activity of recombinant chicken stem cell factor produced by using a baculovirus vector. Zhou, J.H., Ohtaki, M., Inumaru, S., Kitani, H., Sakurai, M. J. Vet. Med. Sci. (1996) [Pubmed]
  16. Expression and purification of biologically active recombinant quail stem cell factor in E. coli. D'Costa, S., Kulik, M.J., Petitte, J.N. Cell Biol. Int. (2000) [Pubmed]
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