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Gene Review

OPN1LW  -  opsin 1 (cone pigments), long-wave...

Gallus gallus

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Disease relevance of OPN1LW

  • The results of previous immunocytochemical and electrophysiological studies of retinas of rd (retinal degeneration) chicks suggest that the iodopsin cone visual pigment may be defective in this mutant [1].

High impact information on OPN1LW


Biological context of OPN1LW


Anatomical context of OPN1LW

  • In the differentiating cones of the developing but immature chick retina, iodopsin immunoreactivity was found at the plasma membranes of both the IS and the terminals (pedicles) [8].
  • However, chicken iodopsin activated the enzyme in frog rod outer segment membrane without irradiation, while chicken rhodopsin did not [9].
  • The chicken retina has several types of cone photoreceptor cells, each of which contains a visual pigment, chicken red (iodopsin), green, blue or violet [10].
  • Monoclonal antibodies (mABs) from hybridoma cells were raised and screened with a purified cone pigment, iodopsin, from the chicken retina [11].

Associations of OPN1LW with chemical compounds


Other interactions of OPN1LW

  • We have purified and reconstituted both chicken rhodopsin and chicken iodopsin and shown them to be phosphorylated by bovine rhodopsin kinase [6].
  • The iodopsin and AANAT mRNA rhythms re-emerged in the cultured retinas within 24 h of removal of the compounds [16].
  • In this study, we compared mRNA levels of iodopsin and the chicken homolog of Clock (cClock) in the retinas of normal and rd (retinal degeneration) chickens that lack functional rod and cone phototransduction cascades [17].
  • To understand the origin of this opsin shift and the mechanism of wavelength regulation in iodopsin, a series of synthetic 9-cis and 11-cis dehydro- and dihydro-retinals was used to regenerate iodopsin-based pigments [18].
  • We compared the rhythmic changes in transcript levels of iodopsin, a photoreceptor-specific gene whose expression is regulated by circadian oscillators, in retinas of normal chickens and GUCY1*B (*B) chickens that carry a null mutation in GC1 [19].

Analytical, diagnostic and therapeutic context of OPN1LW


  1. Molecular and biochemical analyses of iodopsin in rd chick retina. Semple-Rowland, S.L., Green, D.A. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  2. Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture. Pierce, M.E., Sheshberadaran, H., Zhang, Z., Fox, L.E., Applebury, M.L., Takahashi, J.S. Neuron (1993) [Pubmed]
  3. Primary structures of chicken cone visual pigments: vertebrate rhodopsins have evolved out of cone visual pigments. Okano, T., Kojima, D., Fukada, Y., Shichida, Y., Yoshizawa, T. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Cone visual pigments are present in gecko rod cells. Kojima, D., Okano, T., Fukada, Y., Shichida, Y., Yoshizawa, T., Ebrey, T.G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Bathoiodopsin, a primary intermediate of iodopsin at physiological temperature. Kandori, H., Mizukami, T., Okada, T., Imamoto, Y., Fukada, Y., Shichida, Y., Yoshizawa, T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  6. Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Fukada, Y., Kokame, K., Okano, T., Shichida, Y., Yoshizawa, T., McDowell, J.H., Hargrave, P.A., Palczewski, K. Biochemistry (1990) [Pubmed]
  7. Comparative study on the chromophore binding sites of rod and red-sensitive cone visual pigments by use of synthetic retinal isomers and analogues. Fukada, Y., Okano, T., Shichida, Y., Yoshizawa, T., Trehan, A., Mead, D., Denny, M., Asato, A.E., Liu, R.S. Biochemistry (1990) [Pubmed]
  8. Localization of iodopsin in the chick retina during in vivo and in vitro cone differentiation. Araki, M., Fukada, Y., Shichida, Y., Yoshizawa, T. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  9. Activation of phosphodiesterase by chicken iodopsin. Fukada, Y., Yoshizawa, T. FEBS Lett. (1982) [Pubmed]
  10. Identification of the alpha-subunits of rod and cone transducin in chicken photoreceptor cells. Kokame, K., Fukada, Y., Shichida, Y., Okada, M., Honda, Y., Yoshizawa, T. Exp. Eye Res. (1993) [Pubmed]
  11. Monoclonal antibodies specific to chicken iodopsin. Chen, J.G., Nakamura, T., Matsumoto, H., Ebrey, T.G. Vision Res. (1989) [Pubmed]
  12. Effects of chloride on chicken iodopsin and the chromophore transfer reactions from iodopsin to scotopsin and B-photopsin. Shichida, Y., Kato, T., Sasayama, S., Fukada, Y., Yoshizawa, T. Biochemistry (1990) [Pubmed]
  13. Effect of anion binding on iodopsin studied by low-temperature fourier transform infrared spectroscopy. Imamoto, Y., Hirano, T., Imai, H., Kandori, H., Maeda, A., Yoshizawa, T., Groesbeek, M., Lugtenburg, J., Shichida, Y. Biochemistry (1999) [Pubmed]
  14. Nanosecond laser photolysis of iodopsin, a chicken red-sensitive cone visual pigment. Shichida, Y., Okada, T., Kandori, H., Fukada, Y., Yoshizawa, T. Biochemistry (1993) [Pubmed]
  15. Sodium borohydride reduction of iodopsin. Fager, R.S., Kandel, M., Heppner, T., Abrahamson, E.W. Vision Res. (1975) [Pubmed]
  16. Rhythmic expression of clock-controlled genes in retinal photoreceptors is sensitive to 18-beta-glycyrrhetnic acid and 18-alpha-glycyrrhetnic acid-3-hemisuccinate. Zhang, Y., Semple-Rowland, S.L. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  17. Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina. Larkin, P., Baehr, W., Semple-Rowland, S.L. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  18. Wavelength regulation in iodopsin, a cone pigment. Chen, J.G., Nakamura, T., Ebrey, T.G., Ok, H., Konno, K., Derguini, F., Nakanishi, K., Honig, B. Biophys. J. (1989) [Pubmed]
  19. A null mutation in guanylate cyclase-1 alters the temporal dynamics and light entrainment properties of the iodopsin rhythm in cone photoreceptor cells. Larkin, P., Semple-Rowland, S.L. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  20. Chloride effect on iodopsin studied by low-temperature visible and infrared spectroscopies. Hirano, T., Imai, H., Kandori, H., Shichida, Y. Biochemistry (2001) [Pubmed]
  21. Circular dichroism of metaiodopsin II and its binding to transducin: a comparative study between meta II intermediates of iodopsin and rhodopsin. Okada, T., Matsuda, T., Kandori, H., Fukada, Y., Yoshizawa, T., Shichida, Y. Biochemistry (1994) [Pubmed]
  22. Photoreceptor cell types in the retina of various vertebrate species: immunocytochemistry with antibodies against rhodopsin and iodopsin. Kawata, A., Oishi, T., Fukada, Y., Shichida, Y., Yoshizawa, T. Photochem. Photobiol. (1992) [Pubmed]
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