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Gene Review

FZD2  -  frizzled family receptor 2

Gallus gallus

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High impact information on FZD2

  • SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor [1].
  • Chick frizzled-2 (cFz-2) and frizzled-7 (cFz-7) are expressed broadly in cranial ectoderm, tissue that is competent to express markers of the trigeminal placode (Stark et al., 1997. Development 124, 4287-4295; Baker et al., 1999. Development 126, 147-156) [2].

Other interactions of FZD2

  • In addition, cFz-2 and cFz-7 are uniquely expressed in other cranial placodes, including the olfactory, lens, and otic placodes [2].


  1. SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor. Rodriguez, J., Esteve, P., Weinl, C., Ruiz, J.M., Fermin, Y., Trousse, F., Dwivedy, A., Holt, C., Bovolenta, P. Nat. Neurosci. (2005) [Pubmed]
  2. Characterization of avian frizzled genes in cranial placode development. Stark, M.R., Biggs, J.J., Schoenwolf, G.C., Rao, M.S. Mech. Dev. (2000) [Pubmed]
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