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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SFRP1  -  secreted frizzled-related protein 1

Gallus gallus

 
 
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Disease relevance of SFRP1

 

High impact information on SFRP1

  • SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor [2].
  • Furthermore, retroviral mediated expression of a dominant-negative form of GSK3beta induced a retina phenotype similar to that observed after Sfrp1 overexpression, suggesting a possible involvement of this kinase in SFRP1 function [1].
  • Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development [3].
  • Here we show that Frzb-1, which encodes a secreted frizzled-related protein that can bind to Wnt proteins and can antagonize the activity of some Wnts, is expressed in the developing limb bud [4].

References

  1. SFRP1 modulates retina cell differentiation through a beta-catenin-independent mechanism. Esteve, P., Trousse, F., Rodríguez, J., Bovolenta, P. J. Cell. Sci. (2003) [Pubmed]
  2. SFRP1 regulates the growth of retinal ganglion cell axons through the Fz2 receptor. Rodriguez, J., Esteve, P., Weinl, C., Ruiz, J.M., Fermin, Y., Trousse, F., Dwivedy, A., Holt, C., Bovolenta, P. Nat. Neurosci. (2005) [Pubmed]
  3. Sfrp-1 and sfrp-2 are expressed in overlapping and distinct domains during chick development. Terry, K., Magan, H., Baranski, M., Burrus, L.W. Mech. Dev. (2000) [Pubmed]
  4. Involvement of Frzb-1 in mesenchymal condensation and cartilage differentiation in the chick limb bud. Wada, N., Kawakami, Y., Ladher, R., Francis-West, P.H., Nohno, T. Int. J. Dev. Biol. (1999) [Pubmed]
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