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Gene Review

Fzd2  -  frizzled homolog 2 (Drosophila)

Mus musculus

Synonyms: AL033370, AW456835, Frizzled-10, Frizzled-2, Fz-10, ...
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Disease relevance of Fzd2

  • Furthermore, we have reported in previous studies the upregulation of the tissue polarity gene frizzled 2 in myofibroblasts during their migration into the necrotic area after myocardial infarction in the adult heart [1].
  • Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat [2].
  • Our results demonstrate the requirement of two pertussis toxin-sensitive G proteins, Galphao and Galphat, for signaling by the Frizzled-2 receptor [2].

High impact information on Fzd2


Biological context of Fzd2


Anatomical context of Fzd2


Associations of Fzd2 with chemical compounds

  • The discovery of the expression of Gt2 in embryonic cells was co-incident with the demonstration that inhibitors of cyclic GMP phosphodiesterase potently blocked various features of Frizzled-2 signaling in mouse embryonic F9 cells and in zebrafish embryos [7].


  1. Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse. van Gijn, M.E., Blankesteijn, W.M., Smits, J.F., Hierck, B., Gittenberger-de Groot, A.C. Anat. Embryol. (2001) [Pubmed]
  2. Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. Liu, X., Liu, T., Slusarski, D.C., Yang-Snyder, J., Malbon, C.C., Moon, R.T., Wang, H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms. Kennell, J.A., MacDougald, O.A. J. Biol. Chem. (2005) [Pubmed]
  4. Gene profiling of Frizzled-1 and Frizzled-2 signaling: expression of G-protein-coupled receptor chimeras in mouse F9 teratocarcinoma embryonal cells. Li, H., Malbon, C.C., Wang, H.Y. Mol. Pharmacol. (2004) [Pubmed]
  5. Structure and expression of a novel frizzled gene isolated from the developing mouse gut. Malik, T.H., Shivdasani, R.A. Biochem. J. (2000) [Pubmed]
  6. Identification of members of the Wnt signaling pathway in the embryonic pituitary gland. Douglas, K.R., Brinkmeier, M.L., Kennell, J.A., Eswara, P., Harrison, T.A., Patrianakos, A.I., Sprecher, B.S., Potok, M.A., Lyons, R.H., MacDougald, O.A., Camper, S.A. Mamm. Genome (2001) [Pubmed]
  7. WNT-frizzled signaling via cyclic GMP. Wang, H.Y. Front. Biosci. (2004) [Pubmed]
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