High impact information on FZD7

• We have identified a novel frizzled gene in zebrafish, (Danio rerio): frizzled 7, highly related to mouse, chick and Xenopus fz7 [1].
• Expression pattern of the frizzled 7 gene during zebrafish embryonic development [1].
• Chick frizzled-2 (cFz-2) and frizzled-7 (cFz-7) are expressed broadly in cranial ectoderm, tissue that is competent to express markers of the trigeminal placode (Stark et al., 1997. Development 124, 4287-4295; Baker et al., 1999. Development 126, 147-156) [2].
• Comparative genomics on Fzd7 orthologs [3].
• Here we identified and characterized rat Fzd7 gene by using bioinformatics [3].

Anatomical context of FZD7

• To examine the role(s) of Wnt members and their transmembrane-spanning receptor(s), Frizzled (fz), we retrovirally misexpressed Wnt-5a, Wnt-7a, chicken frizzled-1 (Chfz-1), and frizzled-7 (Chfz-7) in long-term (21 day) high density, micromass cultures of stage 23/24 chick embryonic limb mesenchyme [4].

Other interactions of FZD7

• Chick frizzled-1 (cFz-1) is expressed in the lens, otic placode and, along with cFz-7, in epibranchial placodes [2].
• In addition, cFz-2 and cFz-7 are uniquely expressed in other cranial placodes, including the olfactory, lens, and otic placodes [2].

References