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Gene Review

FZD2  -  frizzled class receptor 2

Homo sapiens

Synonyms: Frizzled-2, Fz-2, Fz2, FzE2, fz-2, ...
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Disease relevance of FZD2

  • These results indicate that FZD2, FZD8, and FZD9 might play key roles in human gastric cancer [1].
  • Hence, we investigated the expression and function of five Wnt (Wnt-1, 5a, 7a, 10b, 13) and two Fz (Fz-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) [2].
  • MAIN OUTCOME MEASURE(S): Expression of mRNA transcripts and protein in fibroid compared with myometrium.A more extensive microarray confirmed differential expression of Frizzled-2 and CD-24 but did not confirm Dlk overexpression [3].

High impact information on FZD2


Associations of FZD2 with chemical compounds

  • FZD1, FZD2, and FZD7 share a common structure consisting of seven transmembrane domains, a cysteine-rich domain in the N-terminal extracellular region, and the C-terminal Ser/Thr-Xxx-Val motif [7].

Other interactions of FZD2


Analytical, diagnostic and therapeutic context of FZD2


  1. Expression profiles of 10 members of Frizzled gene family in human gastric cancer. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  2. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Rhee, C.S., Sen, M., Lu, D., Wu, C., Leoni, L., Rubin, J., Corr, M., Carson, D.A. Oncogene (2002) [Pubmed]
  3. Strategy for elucidating differentially expressed genes in leiomyomata identified by microarray technology. Catherino, W.H., Prupas, C., Tsibris, J.C., Leppert, P.C., Payson, M., Nieman, L.K., Segars, J.H. Fertil. Steril. (2003) [Pubmed]
  4. Suppression of Cyclic GMP-dependent Protein Kinase Is Essential to the Wnt/cGMP/Ca2+ Pathway. Ma, L., Wang, H.Y. J. Biol. Chem. (2006) [Pubmed]
  5. Structure and expression of a novel frizzled gene isolated from the developing mouse gut. Malik, T.H., Shivdasani, R.A. Biochem. J. (2000) [Pubmed]
  6. A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1. Zhao, Z., Lee, C.C., Baldini, A., Caskey, C.T. Genomics (1995) [Pubmed]
  7. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. Sagara, N., Toda, G., Hirai, M., Terada, M., Katoh, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  8. Influence of speed variation and age on ground reaction forces and stride parameters of children's normal gait. Diop, M., Rahmani, A., Belli, A., Gautheron, V., Geyssant, A., Cottalorda, J. International journal of sports medicine. (2005) [Pubmed]
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