Disease relevance of FZD2

• These results indicate that FZD2, FZD8, and FZD9 might play key roles in human gastric cancer [1].
• Hence, we investigated the expression and function of five Wnt (Wnt-1, 5a, 7a, 10b, 13) and two Fz (Fz-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) [2].
• MAIN OUTCOME MEASURE(S): Expression of mRNA transcripts and protein in fibroid compared with myometrium.A more extensive microarray confirmed differential expression of Frizzled-2 and CD-24 but did not confirm Dlk overexpression [3].

High impact information on FZD2

• Novel downstream effectors sensing changes in intracellular concentrations of Ca(2+) and cyclic GMP in response to activation of the Wnt/Frizzled-2 pathway were sought [4].
• Moreover, the levels of Wnt-1, 10b, and Fz-2 proteins were also markedly increased in HNSCC, relative to normal epithelial cells [2].
• The amino acid sequence of Mfz10 is nearly identical to that of human FzE2 (also known as FzD2) [5].
• The FZD2 gene was isolated from a human ovarian cDNA library and mapped to 17q21.1 by fluorescent in situ hybridization (FISH) with a corresponding cosmid [6].
• RT-PCR and real-time PCR demonstrated equivalent Dlk mRNA expression between fibroid and myometrium (ratio, 1.02), a slight Frizzled-2 overexpression (ratio, 2.09), and robust CD-24 overexpression in fibroids (ratio, 12.35) [3].

Associations of FZD2 with chemical compounds

• FZD1, FZD2, and FZD7 share a common structure consisting of seven transmembrane domains, a cysteine-rich domain in the N-terminal extracellular region, and the C-terminal Ser/Thr-Xxx-Val motif [7].

Other interactions of FZD2

• Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 [7].
• The minimum vertical force (Fz2), the second vertical peak force (Fz3), and the duration of stride and stance were significantly higher in groups 2 and 3 [8].

Analytical, diagnostic and therapeutic context of FZD2

• Western blot and immunohistochemistry confirmed Frizzled-2 overexpression, but did not confirm Dlk overexpression [3].

References