The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ID2  -  inhibitor of DNA binding 2, dominant...

Homo sapiens

Synonyms: BHLHB26, Class B basic helix-loop-helix protein 26, DNA-binding protein inhibitor ID-2, GIG8, ID2A, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ID2


High impact information on ID2

  • Similar studies with the endonuclease MspI revealed alleles of many different sizes (the difference was due to an insertion-deletion polymorphism), which we grouped as larger and smaller alleles and designated as ID1 and ID2, respectively [7].
  • We show here that ID2, which can inactivate E2A and perhaps PAX5, is not detectable in normal B cells but is strongly and uniformly expressed in HRS cells of all cases of classical HL [3].
  • The binding surface on SMRT is mapped to the C-terminal ID2 region, and mutation in the ID2 corepressor motif inhibits the interaction [8].
  • Several genes (IGF-BP3, ID2, and ID3) showed similar responses (increased expression) to DBP and rhBMP-2 [9].
  • These data, obtained in two independent laboratories, challenge the previously proposed ID2-MYCN relation [1].

Biological context of ID2


Anatomical context of ID2

  • As these results are of potential clinical importance, but not in agreement with our own initial observations, the putative correlation between ID2 and MYC(N) expression in neuroblastoma cell lines and tumors was reinvestigated [1].
  • ID1 stained the hepatocytes of both LEA and LEC rats, whereas ID2 stained LEA rat hepatocytes only [13].
  • Evaluation of BBL CHROMagar and CPS ID2 media for detection and presumptive identification of urinary tract pathogens [14].
  • This laboratory study was conducted to assess the safety of a new interdental cleaner, the Braun Oral-B Interclean (ID2), by measuring its abrasivity to dentin and comparing this with the abrasivity of a standard ADA manual toothbrush when used with and without dentifrice [15].
  • Time resolved X-ray diffraction experiments in single muscle fibres of the frog at 2.15 microns sarcomere length and 4 degrees C were performed at ID2 (SAXS), ESRF, Grenoble (France) to investigate the structural aspects of cross-bridge action during the development of the isometric tetanic tension (T0) [16].

Associations of ID2 with chemical compounds

  • These results indicate that ID1 and ID2 are important retinoic acid responsive genes in APL, and suggest that the inhibition of specific bHLH transcription factor complexes may play a role in the therapeutic effect of ATRA in APL [10].
  • The relevance of these findings was further studied after interfering p53 expression in MCF7 cells (shp53 cells), showing a lower induction of both, ID1 and ID2 transcripts, after 5-FU when compared with MCF7 shGFP control cells [17].
  • The API 20E gave "no identification" for 13.1% of the isolates, while the Neg ID2, GNI+, ID-GNB, and Crystal were unable to identify 1.8, 2.9, 5.0, and 6.9%, respectively [18].
  • Monoclonal antibody, ID2, which has similar reactivity as human aPL, significantly decreased the apparent abundance of nuclear Stat5b in response to cAMP/MPA and was associated with decreased decidual PRL promoter activation and PRL secretion [19].
  • In comparison with Albicans ID2 and Sabouraud gentamicin chloramphenicol on 446 fungal strains, Candida ID allowed the isolation of more species than Albicans ID 2 (95.5% versus 91.2%) [20].

Physical interactions of ID2

  • Functional analysis suggests that only ID1 may work as a pore-occluding ball domain, whereas ID2 most likely acts as a "docking domain" that attaches ID1 to the cytoplasmic face of the channel [21].

Regulatory relationships of ID2


Other interactions of ID2

  • Chromosomal assignment of human ID1 and ID2 genes [22].
  • The simultaneous upregulation of ID1 and ID2, and the downregulation of E2A suggest a role for bHLH proteins in the induction of differentiation of APL cells following ATRA treatment [10].
  • The ~50 genes upregulated early after Wnt addition include the previously known Wnt targets Cyclin D1, MYC, ID2 and betaTRCP [23].
  • Three candidate genes, KCNF1, ID2 and ATP6V1C2 were sequenced, and were found to be negative for functional sequence variants [24].
  • In conclusion, elevated expression of ID2 and DCN was significantly associated with poor prognosis in a homogeneous group of ovarian cancer patients for whom survival could not be predicted from clinical factors [25].

Analytical, diagnostic and therapeutic context of ID2


  1. ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Vandesompele, J., Edsjö, A., De Preter, K., Axelson, H., Speleman, F., Påhlman, S. Oncogene (2003) [Pubmed]
  2. Expression of ID genes in differentiated elements of human male germ cell tumors. Albanese, J.M., Reuter, V.E., Bosl, G.J., Houldsworth, J., Chaganti, R.S. Diagn. Mol. Pathol. (2001) [Pubmed]
  3. Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma. Renné, C., Martin-Subero, J.I., Eickernjäger, M., Hansmann, M.L., Küppers, R., Siebert, R., Bräuninger, A. Am. J. Pathol. (2006) [Pubmed]
  4. High ID2 protein expression correlates with a favourable prognosis in patients with primary breast cancer and reduces cellular invasiveness of breast cancer cells. Stighall, M., Manetopoulos, C., Axelson, H., Landberg, G. Int. J. Cancer (2005) [Pubmed]
  5. Patterns of gene expression in pituitary carcinomas and adenomas analyzed by high-density oligonucleotide arrays, reverse transcriptase-quantitative PCR, and protein expression. Ruebel, K.H., Leontovich, A.A., Jin, L., Stilling, G.A., Zhang, H., Qian, X., Nakamura, N., Scheithauer, B.W., Kovacs, K., Lloyd, R.V. Endocrine (2006) [Pubmed]
  6. Decreased ID2 promotes metastatic potentials of hepatocellular carcinoma by altering secretion of vascular endothelial growth factor. Tsunedomi, R., Iizuka, N., Tamesa, T., Sakamoto, K., Hamaguchi, T., Somura, H., Yamada, M., Oka, M. Clin. Cancer Res. (2008) [Pubmed]
  7. Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction. Hegele, R.A., Huang, L.S., Herbert, P.N., Blum, C.B., Buring, J.E., Hennekens, C.H., Breslow, J.L. N. Engl. J. Med. (1986) [Pubmed]
  8. Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT. Liao, G., Chen, L.Y., Zhang, A., Godavarthy, A., Xia, F., Ghosh, J.C., Li, H., Chen, J.D. J. Biol. Chem. (2003) [Pubmed]
  9. Comparison of TGF-beta/BMP pathways signaled by demineralized bone powder and BMP-2 in human dermal fibroblasts. Zhou, S., Glowacki, J., Yates, K.E. J. Bone Miner. Res. (2004) [Pubmed]
  10. ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells. Nigten, J., Breems-de Ridder, M.C., Erpelinck-Verschueren, C.A., Nikoloski, G., van der Reijden, B.A., van Wageningen, S., van Hennik, P.B., de Witte, T., Löwenberg, B., Jansen, J.H. Leukemia (2005) [Pubmed]
  11. Expression profiles and clinical relationships of ID2, CDKN1B, and CDKN2A in primary neuroblastoma. Gebauer, S., Yu, A.L., Omura-Minamisawa, M., Batova, A., Diccianni, M.B. Genes Chromosomes Cancer (2004) [Pubmed]
  12. Down-regulation of ID2 by all-trans retinoic acid in monocytic leukemia cells (THP-1). Wågsäter, D., Sirsjö, A., Dimberg, J. J. Exp. Clin. Cancer Res. (2003) [Pubmed]
  13. Lack of copper binding sites in ceruloplasmin of LEC rats with abnormal copper metabolism. Hiyamuta, S., Takeichi, N. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  14. Evaluation of BBL CHROMagar and CPS ID2 media for detection and presumptive identification of urinary tract pathogens. Arya, S.C. J. Clin. Microbiol. (1998) [Pubmed]
  15. Hard tissue abrasivity of an automatic interdental plaque remover. Schemehorn, B.R., Zwart, A.C. The Journal of clinical dentistry. (1996) [Pubmed]
  16. Myosin head movements during isometric contraction studied by X-ray diffraction of single frog muscle fibres. Reconditi, M., Dobbie, I., Irving, M., Diat, O., Boesecke, P., Linari, M., Piazzesi, G., Lombardi, V. Adv. Exp. Med. Biol. (1998) [Pubmed]
  17. Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Hernández-Vargas, H., Ballestar, E., Carmona-Saez, P., von Kobbe, C., Bañón-Rodríguez, I., Esteller, M., Moreno-Bueno, G., Palacios, J. Int. J. Cancer (2006) [Pubmed]
  18. Accuracy of six commercially available systems for identification of members of the family vibrionaceae. O'Hara, C.M., Sowers, E.G., Bopp, C.A., Duda, S.B., Strockbine, N.A. J. Clin. Microbiol. (2003) [Pubmed]
  19. Regulated expression of signal transducer and activator of transcription, Stat5, and its enhancement of PRL expression in human endometrial stromal cells in vitro. Mak, I.Y., Brosens, J.J., Christian, M., Hills, F.A., Chamley, L., Regan, L., White, J.O. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  20. Evaluation of Candida ID, a new chromogenic medium for fungal isolation and preliminary identification of some yeast species. Fricker-Hidalgo, H., Orenga, S., Lebeau, B., Pelloux, H., Brenier-Pinchart, M.P., Ambroise-Thomas, P., Grillot, R. J. Clin. Microbiol. (2001) [Pubmed]
  21. Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4. Wissmann, R., Bildl, W., Oliver, D., Beyermann, M., Kalbitzer, H.R., Bentrop, D., Fakler, B. J. Biol. Chem. (2003) [Pubmed]
  22. Chromosomal assignment of human ID1 and ID2 genes. Mathew, S., Chen, W., Murty, V.V., Benezra, R., Chaganti, R.S. Genomics (1995) [Pubmed]
  23. A transcriptional response to Wnt protein in human embryonic carcinoma cells. Willert, J., Epping, M., Pollack, J.R., Brown, P.O., Nusse, R. BMC Dev. Biol. (2002) [Pubmed]
  24. A novel autosomal recessive non-syndromic hearing impairment locus (DFNB47) maps to chromosome 2p25.1-p24.3. Hassan, M.J., Santos, R.L., Rafiq, M.A., Chahrour, M.H., Pham, T.L., Wajid, M., Hijab, N., Wambangco, M., Lee, K., Ansar, M., Yan, K., Ahmad, W., Leal, S.M. Hum. Genet. (2006) [Pubmed]
  25. Expression profiling correlates with treatment response in women with advanced serous epithelial ovarian cancer. Newton, T.R., Parsons, P.G., Lincoln, D.J., Cummings, M.C., Wyld, D.K., Webb, P.M., Green, A.C., Boyle, G.M. Int. J. Cancer (2006) [Pubmed]
  26. Prognostic value of MYCN and ID2 overexpression in neuroblastoma. Alaminos, M., Gerald, W.L., Cheung, N.K. Pediatric blood & cancer. (2005) [Pubmed]
  27. Evaluation of CPS ID2 medium for detection of urinary tract bacterial isolates in specimens from a rehabilitation center. Mazoyer, M.A., Orenga, S., Doleans, F., Freney, J. J. Clin. Microbiol. (1995) [Pubmed]
  28. Identification of ID2 associated with invasion of hepatitis C virus-related hepatocellular carcinoma by gene expression profile. Tsunedomi, R., Iizuka, N., Yamada-Okabe, H., Tamesa, T., Okada, T., Sakamoto, K., Takashima, M., Hamaguchi, T., Miyamoto, T., Uchimura, S., Hamamoto, Y., Yamada, M., Oka, M. Int. J. Oncol. (2006) [Pubmed]
  29. An investigation of the efficacy and safety of a new electric interdental plaque remover for the reduction of interproximal plaque and gingivitis. Cronin, M., Dembling, W. The Journal of clinical dentistry. (1996) [Pubmed]
WikiGenes - Universities