Disease relevance of Dde_0286

• Methanosarcina barkeri ferredoxin and Desulfovibrio desulfuricans ferredoxin II are of interest because, of all the ferredoxins whose sequences are presently known, they show the strongest evidence of internal gene duplication.(ABSTRACT TRUNCATED AT 400 WORDS)[1]

High impact information on Dde_0286

• A synthetic gene coding for a modified ferredoxin II of Desulfovibrio desulfuricans Norway strain was assembled from 10 oligonucleotides [2].
• The amino acid sequence of ferredoxin I is reported and compared to the ferredoxin II sequence [3].
• Ferredoxin II, covalently cross-linked with either cytochrome c3 or c553, is an obligate intermediate in cytochrome reduction by pyruvate dehydrogenase [4].
• Ferredoxin II when reduced, at first showed a more complex spectrum, indicating an interaction between two [4Fe-4S] clusters, and probably, has two clusters per protein subunit [5].
• Ferredoxin II is more acidic and abundant than ferredoxin I, but is very unstable to O2 [6].

Biological context of Dde_0286

• The comparison of amino-acid sequences shows that ferredoxin II presents more homologies with clostridial type ferredoxin than with the ferredoxins from D. gigas and D. africanus [7].

Analytical, diagnostic and therapeutic context of Dde_0286

• Upon reductive titration ferredoxin II changed to give a spectrum in which no intercluster interaction was seen [5].

References