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Gene Review:

l(2)efl - lethal (2) essential for life

Drosophila melanogaster

Synonyms: CG4533, Cryab, Dmel\CG4533, L(2)efl, Protein Efl21, ...

Shirk, P.D. et al., Kurzik-Dumke, U. et al.

Shirk, Broza, Hemphill, Perera,

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High impact information on l(2)efl

In this study, we report the molecular cloning of a novel Drosophila melanogaster small heat-shock (HS)-homologous gene, l(2)efl, identified on the right arm of the second chromosome at locus 59F4,5 [1].
In addition to the sequence for l(2)efl, the predicted amino acid sequence for acp25 also showed significant sequence similarly with the alpha-crystallin A chain polypeptides from the lenses of vertebrae eyes [2].
An N-terminal hydrophobic aggregation site and a C-terminal protective binding site common to alpha-crystallin proteins were present in the predicted acp25 and l(2)efl amino acid sequences, while only the C-terminal protective binding site was present in the small heat shock protein sequences from D. melanogaster [2].
Both the DNA sequence and predicted amino acid sequence showed considerable homology with the embryonic lethal gene, l(2)efl, in Drosophila melanogaster [2].

References

Sequence of the new Drosophila melanogaster small heat-shock-related gene, lethal(2) essential for life [l(2)efl], at locus 59F4,5. Kurzik-Dumke, U., Lohmann, E. Gene (1995) [Pubmed]
alpha-Crystallin protein cognates in eggs of the moth, Plodia interpunctella: possible chaperones for the follicular epithelium yolk protein. Shirk, P.D., Broza, R., Hemphill, M., Perera, O.P. Insect Biochem. Mol. Biol. (1998) [Pubmed]

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AgaP_AGAP007162	Anopheles gambiae str. PEST
CRYAB	Bos taurus
CRYAB	Canis lupus familiaris
cryabb	Danio rerio
CRYAB	Gallus gallus
CRYAB	Homo sapiens
CRYAB	Macaca mulatta
Cryab	Mus musculus
CRYAB	Pan troglodytes
Cryab	Rattus norvegicus
cryab	Xenopus (Silurana) tropicalis

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