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Gene Review

Cryab  -  crystallin, alpha B

Mus musculus

Synonyms: Alpha(B)-crystallin, Alpha-crystallin B chain, Crya-2, Crya2, HspB5, ...
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Disease relevance of Cryab


High impact information on Cryab


Chemical compound and disease context of Cryab


Biological context of Cryab


Anatomical context of Cryab


Associations of Cryab with chemical compounds


Regulatory relationships of Cryab

  • The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation [19].
  • The expression of heat shock protein hsp 27 was up-regulated whereas alpha B-crystallin was down-regulated in different areas of HSF1 null mouse brain in comparison to control mice [20].

Other interactions of Cryab


Analytical, diagnostic and therapeutic context of Cryab


  1. Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. Martindale, J.J., Wall, J.A., Martinez-Longoria, D.M., Aryal, P., Rockman, H.A., Guo, Y., Bolli, R., Glembotski, C.C. J. Biol. Chem. (2005) [Pubmed]
  2. Alpha B-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain. Iwaki, T., Kume-Iwaki, A., Liem, R.K., Goldman, J.E. Cell (1989) [Pubmed]
  3. Regulation of the murine alpha B-crystallin/small heat shock protein gene in cardiac muscle. Gopal-Srivastava, R., Haynes, J.I., Piatigorsky, J. Mol. Cell. Biol. (1995) [Pubmed]
  4. Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain. Che, Y., Piao, C.S., Han, P.L., Lee, J.K. J. Neurosci. Res. (2001) [Pubmed]
  5. alpha-Crystallin: molecular chaperone and heat shock protein. van den IJssel, P.R., Smulders, R.H., de Jong, W.W., Bloemendal, H. Ophthalmic Res. (1996) [Pubmed]
  6. Expression of the murine small heat shock proteins hsp 25 and alpha B crystallin in the absence of stress. Klemenz, R., Andres, A.C., Fröhli, E., Schäfer, R., Aoyama, A. J. Cell Biol. (1993) [Pubmed]
  7. Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin. Brady, J.P., Garland, D., Duglas-Tabor, Y., Robison, W.G., Groome, A., Wawrousek, E.F. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription. Chang, Y., Abe, A., Shayman, J.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Alpha B-crystallin is a small heat shock protein. Klemenz, R., Fröhli, E., Steiger, R.H., Schäfer, R., Aoyama, A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  10. Upregulation of rat P23 (a member of the YjgF protein family) by fasting, glucose diet and fatty acid feeding. Levy-Favatier, F., Leroux, A., Antoine, B., Nedelec, B., Delpech, M. Cell. Mol. Life Sci. (2004) [Pubmed]
  11. The progressive rise in the expression of alpha crystallin B chain in human endometrium is initiated during the implantation window: modulation of gene expression by steroid hormones. Gruidl, M., Buyuksal, A., Babaknia, A., Fazleabas, A.T., Sivarajah, S., Satyaswaroop, P.G., Tabibzadeh, S. Mol. Hum. Reprod. (1997) [Pubmed]
  12. Orientation-dependent influence of an intergenic enhancer on the promoter activity of the divergently transcribed mouse Shsp/alpha B-crystallin and Mkbp/HspB2 genes. Swamynathan, S.K., Piatigorsky, J. J. Biol. Chem. (2002) [Pubmed]
  13. Differential expression of alpha A- and alpha B-crystallin during murine ocular development. Robinson, M.L., Overbeek, P.A. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  14. Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes. Quax-Jeuken, Y., Quax, W., van Rens, G., Khan, P.M., Bloemendal, H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  15. Alpha B crystallin accumulation is a specific response to Ha-ras and v-mos oncogene expression in mouse NIH 3T3 fibroblasts. Klemenz, R., Fröhli, E., Aoyama, A., Hoffmann, S., Simpson, R.J., Moritz, R.L., Schäfer, R. Mol. Cell. Biol. (1991) [Pubmed]
  16. Expression of the murine alpha B-crystallin gene is not restricted to the lens. Dubin, R.A., Wawrousek, E.F., Piatigorsky, J. Mol. Cell. Biol. (1989) [Pubmed]
  17. Spatial and temporal activity of the alpha B-crystallin/small heat shock protein gene promoter in transgenic mice. Haynes, J.I., Duncan, M.K., Piatigorsky, J. Dev. Dyn. (1996) [Pubmed]
  18. Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens. Boyle, D.L., Takemoto, L., Brady, J.P., Wawrousek, E.F. BMC ophthalmology [electronic resource]. (2003) [Pubmed]
  19. The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation. Kamradt, M.C., Chen, F., Sam, S., Cryns, V.L. J. Biol. Chem. (2002) [Pubmed]
  20. Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain. Santos, S.D., Saraiva, M.J. Neuroscience (2004) [Pubmed]
  21. Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones. Merck, K.B., Groenen, P.J., Voorter, C.E., de Haard-Hoekman, W.A., Horwitz, J., Bloemendal, H., de Jong, W.W. J. Biol. Chem. (1993) [Pubmed]
  22. Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains. Yang, Q., Osinska, H., Klevitsky, R., Robbins, J. J. Mol. Cell. Cardiol. (2001) [Pubmed]
  23. Multifunctional lens crystallins and corneal enzymes. More than meets the eye. Piatigorsky, J. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  24. The murine alpha B-crystallin/small heat shock protein enhancer: identification of alpha BE-1, alpha BE-2, alpha BE-3, and MRF control elements. Gopal-Srivastava, R., Piatigorsky, J. Mol. Cell. Biol. (1993) [Pubmed]
  25. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. Kamradt, M.C., Lu, M., Werner, M.E., Kwan, T., Chen, F., Strohecker, A., Oshita, S., Wilkinson, J.C., Yu, C., Oliver, P.G., Duckett, C.S., Buchsbaum, D.J., LoBuglio, A.F., Jordan, V.C., Cryns, V.L. J. Biol. Chem. (2005) [Pubmed]
  26. Role of immunoglobulin A monoclonal antibodies against P23 in controlling murine Cryptosporidium parvum infection. Enriquez, F.J., Riggs, M.W. Infect. Immun. (1998) [Pubmed]
  27. Differential effect of 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) on alpha B-crystallin and hsp70 gene expression in murine cell lines. Lee, Y.J., Berns, C.M., Galoforo, S., Erdos, G., Cho, J.M., Corry, P.M. Biochem. Pharmacol. (1995) [Pubmed]
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