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Gene Review

cx35b  -  connexin 35b

Danio rerio

Synonyms: SO:0000704, connexin35, cx35, gja9
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High impact information on cx35

  • In the present study, we have shown that Cx35 expression in Xenopus oocytes and N2A cells produced large outward whole cell currents on cell depolarization [1].
  • Using whole cell, cell-attached, and excised patch configurations, we obtained multichannel and single-channel current recordings attributable to the Cx35 hemichannels (I(hc)) that were activated and increased by stepwise depolarization of membrane potential (V(m)) and deactivated by hyperpolarization [1].
  • Extrapolation to V(m) = 0 mV predicted a gamma(hc) of 48 pS, suggesting a unitary conductance of intact Cx35 gap junction channels of approximately 24 pS [1].
  • In this study, zebrafish connexin35 has been cloned from a P1 artificial chromosome (PAC) library [2].

Anatomical context of cx35

  • However, water-injected oocytes that were not treated with antisense showed activities attributable to Cx38 hemichannels that were easily distinguishable from Cx35 hemichannels by a significantly larger unitary conductance (gamma(hc): 250-320 pS) [1].


  1. Biophysical characterization of zebrafish connexin35 hemichannels. Valiunas, V., Mui, R., McLachlan, E., Valdimarsson, G., Brink, P.R., White, T.W. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
  2. Zebrafish Cx35: cloning and characterization of a gap junction gene highly expressed in the retina. McLachlan, E., White, T.W., Ugonabo, C., Olson, C., Nagy, J.I., Valdimarsson, G. J. Neurosci. Res. (2003) [Pubmed]
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