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Gene Review

fmhB  -  methicillin resistance factor...

Staphylococcus aureus RF122

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Disease relevance of fmhB


High impact information on fmhB

  • The factor catalyzing the first step in the synthesis of the characteristic pentaglycine interpeptide in Staphylococcus aureus peptidoglycan was found to be encoded by the essential gene fmhB [1].
  • Any shortening of the pentaglycine side chain reduces or even abolishes methicillin resistance, as occurred with fmhB repression [1].
  • The endogenous fmhB promoter was substituted with the xylose regulon from Staphylococcus xylosus, which allowed glucose-controlled repression of fmhB transcription [1].
  • Expression of the fmhB, femA, and femB genes of S. aureus in E. faecalis led to the production of peptidoglycan precursors substituted by mosaic side chains that were efficiently used by the penicillin-binding proteins for cross-bridge formation [2].
  • A spontaneous mutant of SA137/93G with higher sensitivity to vancomycin displayed a cell wall profile similar, in some respects, to that of an fmhB mutant [3].

Other interactions of fmhB

  • Whereas insertional inactivation of fmhA and fmhC had no effects on growth, antibiotic susceptibility, lysostaphin resistance, or peptidoglycan composition of the strains, fmhB could not be inactivated, strongly suggesting that fmhB may be an essential gene [4].


  1. The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation. Rohrer, S., Ehlert, K., Tschierske, M., Labischinski, H., Berger-Bächi, B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Synthesis of mosaic peptidoglycan cross-bridges by hybrid peptidoglycan assembly pathways in gram-positive bacteria. Arbeloa, A., Hugonnet, J.E., Sentilhes, A.C., Josseaume, N., Dubost, L., Monsempes, C., Blanot, D., Brouard, J.P., Arthur, M. J. Biol. Chem. (2004) [Pubmed]
  3. Morphological and genetic differences in two isogenic Staphylococcus aureus strains with decreased susceptibilities to vancomycin. Reipert, A., Ehlert, K., Kast, T., Bierbaum, G. Antimicrob. Agents Chemother. (2003) [Pubmed]
  4. Identification of three additional femAB-like open reading frames in Staphylococcus aureus. Tschierske, M., Mori, C., Rohrer, S., Ehlert, K., Shaw, K.J., Berger-Bächi, B. FEMS Microbiol. Lett. (1999) [Pubmed]
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