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Chemical Compound Review

pentaglycine     2-[2-[2-[2-(2- aminoethanoylamino) ethanoyla...

Synonyms: CHEMBL14390, AG-G-77396, G5755_SIGMA, NSC-96353, CHEBI:114248, ...
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Disease relevance of pentaglycine


High impact information on pentaglycine


Chemical compound and disease context of pentaglycine


Biological context of pentaglycine


Anatomical context of pentaglycine


Associations of pentaglycine with other chemical compounds


Gene context of pentaglycine

  • To explore Arg(19) and the midregion (residues 10-15), we designed the novel PTH scaffold peptide, PG5, which has the PTH(1-9) domain linked to the PTH(15-31) segment via a pentaglycine spacer [16].
  • Lysostaphin is an endopeptidase that cleaves the pentaglycine cross-bridges of the staphylococcal cell wall rapidly lysing the bacteria [17].
  • Sortase B of S. aureus recognizes a motif NPQTN, cleaves the polypeptide after the Thr residue, and attaches the protein to pentaglycine cross-bridges [18].
  • The apparent activation energy of hydrolysis of pentaglycine bridges in Staphylococcus peptidoglycan is 77.9 kJ/mol [19].


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  3. The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation. Rohrer, S., Ehlert, K., Tschierske, M., Labischinski, H., Berger-Bächi, B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
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  11. Specific effects of synthetic oligopeptides on cultured animal cells. Franek, F., Katinger, H. Biotechnol. Prog. (2002) [Pubmed]
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  14. Lysostaphin cream eradicates Staphylococcus aureus nasal colonization in a cotton rat model. Kokai-Kun, J.F., Walsh, S.M., Chanturiya, T., Mond, J.J. Antimicrob. Agents Chemother. (2003) [Pubmed]
  15. Rotating ring-disk electrode study of copper(II) complexes of the model peptides triglycine, tetraglycine, and pentaglycine. Woltman, S.J., Alward, M.R., Weber, S.G. Anal. Chem. (1995) [Pubmed]
  16. Cooperative interaction of arginine-19 and the N-terminal signaling domain in the affinity and potency of parathyroid hormone. Tsomaia, N., Shimizu, M., Shimizu, N., Gardella, T.J., Mierke, D.F. Biochemistry (2004) [Pubmed]
  17. Comparison of four methods for determining lysostaphin susceptibility of various strains of Staphylococcus aureus. Kusuma, C.M., Kokai-Kun, J.F. Antimicrob. Agents Chemother. (2005) [Pubmed]
  18. Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site. Zhang, R., Wu, R., Joachimiak, G., Mazmanian, S.K., Missiakas, D.M., Gornicki, P., Schneewind, O., Joachimiak, A. Structure (2004) [Pubmed]
  19. Michaelis-menten kinetics for determining enzymatic activity of lysostaphin. Surovtsev, V.I., Fedorov, T.V., Borozdina, M.A. Biochemistry Mosc. (2004) [Pubmed]
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