Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Zfp488 - zinc finger protein 488

Mus musculus

Synonyms: Gm1206, LOC382867, Zinc finger protein 488, Znf488

Wang, S.Z. et al.

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High impact information on Zfp488

In the developing CNS, Zfp488 is specifically expressed in oligodendrocytes but not their precursors [1].
In this study, we identified Zfp488, an oligodendrocyte-specific zinc-finger transcription regulator, by screening for genes downregulated in the optic nerves of Olig1-null mice [1].
Furthermore, knockdown of Zfp488 via RNAi in an oligodendroglial cell line leads to the downregulation of myelin gene expression [1].

Biological context of Zfp488

Taken together, these data suggest that Zfp488 functions as an oligodendrocyte-specific transcription co-regulator important for oligodendrocyte maturation and that zinc-finger/bHLH cooperation can serve as a mechanism for oligodendroglial differentiation [1].

References

An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Wang, S.Z., Dulin, J., Wu, H., Hurlock, E., Lee, S.E., Jansson, K., Lu, Q.R. Development (2006) [Pubmed]

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