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Gene Review

FMRFaR  -  FMRFamide Receptor

Drosophila melanogaster

Synonyms: CG2114, DFR, Dm FMRFa-R, Dmel\CG2114, DrmFMRFa-R, ...
 
 
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High impact information on FR

  • To our knowledge, the cloned DrmFMRFa-R is the first functionally active FMRFamide G protein-coupled receptor described in invertebrates to date [1].
  • The full-length ORF of a D. melanogaster orphan receptor, CG 2114 (Berkeley Drosophila Genome Project), was cloned from genomic DNA [1].
  • However, this is not justified anymore, because the insect myosuppressin receptor/ligand couple is both functionally and evolutionarily fully unrelated to the insect FMRFamide receptor/ligand couple [2].
 

Biological context of FR

 

Analytical, diagnostic and therapeutic context of FR

References

  1. Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor. Meeusen, T., Mertens, I., Clynen, E., Baggerman, G., Nichols, R., Nachman, R.J., Huybrechts, R., De Loof, A., Schoofs, L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Molecular identification of a myosuppressin receptor from the malaria mosquito Anopheles gambiae. Schöller, S., Belmont, M., Cazzamali, G., Hauser, F., Williamson, M., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  3. The structure of the FMRFamide receptor and activity of the cardioexcitatory neuropeptide are conserved in mosquito. Duttlinger, A., Mispelon, M., Nichols, R. Neuropeptides (2003) [Pubmed]
  4. Molecular cloning and functional expression of the first insect FMRFamide receptor. Cazzamali, G., Grimmelikhuijzen, C.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
 
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