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Gene Review

Ms  -  Myosuppressin

Drosophila melanogaster

Synonyms: CG6440, DMS, Dm-MS, Dmel\CG6440, Dms, ...
 
 
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Disease relevance of Dms

  • Dromyosuppressin-like immunoreactive fibers were detected in the cardiac recurrent nerve, hypocerebral ganglion/corpora cardiaca complex, crop duct, and crop [1].
  • DMS and DES are monofunctional alkylating agents that have been shown to induce mutations, chromosomal aberrations, and other genetic alterations in a diversity of organisms [2].
 

High impact information on Dms

 

Chemical compound and disease context of Dms

 

Biological context of Dms

  • To determine the neuronal expression patterns of these structurally related peptides, we have generated DMS- and DSK-specific antisera to multiple antigenic peptides and performed double-label immunochemistry with antisera raised on different animals of the same species host animal [4].
  • We have used the genomic sequence information from the malaria mosquito Anopheles gambiae Genome Project to clone a G protein-coupled receptor that was closely related to the two previously cloned and characterized myosuppressin receptors from Drosophila [Proc. Natl. Acad. Sci. USA 100 (2003) 9808] [5].
  • Dromyosuppressin (DMS; TDVDHVFLRFamide) is an abundant peptide isolated from adult Drosophila which shares a high degree of sequence homology with peptides isolated from chicken, cockroach, fleshfly, and locust [6].
  • Ability to break chromosomes, as indicated by the T : M ratios, decreased in the sequence MMS greater than or equal to DMS, MNU greater than DMN greater than EMS greater than iPMS greater than ENU = DEN [7].
 

Anatomical context of Dms

 

Associations of Dms with chemical compounds

 

Physical interactions of Dms

  • However, this is not justified anymore, because the insect myosuppressin receptor/ligand couple is both functionally and evolutionarily fully unrelated to the insect FMRFamide receptor/ligand couple [5].
 

Other interactions of Dms

  • TPAEDFMRFamide and DMS each contains a RFamide C-terminus; however, their effects on crop contractions differ, which suggests that unique receptors or different ligand:receptor binding requirements exist for these structurally related peptides [9].
 

Analytical, diagnostic and therapeutic context of Dms

References

  1. Innervation of dromyosuppressin (DMS) immunoreactive processes and effect of DMS and benzethonium chloride on the Phormia regina (Meigen) crop. Richer, S., Stoffolano, J.G., Yin, C.M., Nichols, R. J. Comp. Neurol. (2000) [Pubmed]
  2. Genetic effects of dimethyl sulfate, diethyl sulfate, and related compounds. Hoffmann, G.R. Mutat. Res. (1980) [Pubmed]
  3. O-alkylation in DNA does not correlate with the formation of chromosome breakage events in D. melanogaster. Vogel, E.W. Mutat. Res. (1986) [Pubmed]
  4. Dromyosuppressin and drosulfakinin, two structurally related Drosophila neuropeptides, are uniquely expressed in the adult central nervous system. Nichols, R., McCormick, J., Lim, I. Ann. N. Y. Acad. Sci. (1997) [Pubmed]
  5. Molecular identification of a myosuppressin receptor from the malaria mosquito Anopheles gambiae. Schöller, S., Belmont, M., Cazzamali, G., Hauser, F., Williamson, M., Grimmelikhuijzen, C.J. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. Immunocytochemistry of sequence-related neuropeptides in Drosophila. Tibbetts, M.F., Nichols, R. Neuropeptides (1993) [Pubmed]
  7. The relation between reaction kinetics and mutagenic action of mono-functional alkylating agents in higher eukaryotic systems. I. Recessive lethal mutations and translocations in Drosophila. Vogel, E., Natarajan, A.T. Mutat. Res. (1979) [Pubmed]
  8. Spatial and temporal expression identify dromyosuppressin as a brain-gut peptide in Drosophila melanogaster. McCormick, J., Nichols, R. J. Comp. Neurol. (1993) [Pubmed]
  9. The different effects of three Drosophila melanogaster dFMRFamide-containing peptides on crop contractions suggest these structurally related peptides do not play redundant functions in gut. Duttlinger, A., Berry, K., Nichols, R. Peptides (2002) [Pubmed]
  10. Molecular cloning and functional expression of the first two specific insect myosuppressin receptors. Egerod, K., Reynisson, E., Hauser, F., Cazzamali, G., Williamson, M., Grimmelikhuijzen, C.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
 
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