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Gene Review

Gr66a  -  Gustatory receptor 66a

Drosophila melanogaster

Synonyms: CG7189, Dmel\CG7189, GR66A, GR66C1, GR66a, ...
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Disease relevance of Gr66a

  • Moreover, tetanus toxin-mediated inactivation of Gr66a- or Gr5a-expressing cells shows that these two sets of neurons mediate distinct taste modalities-the perception of bitter (caffeine) and sweet (trehalose) taste, respectively [1].

High impact information on Gr66a

  • In a behavioral assay, the aversion to caffeine was specifically disrupted in flies missing Gr66a [2].
  • Given that theobromine and caffeine inhibit PDEs with equal potencies , these data further support the role of Gr66a rather than a PDE in mediating the caffeine response [2].
  • The Gr66a mutant exhibited normal tastant-induced action potentials upon presentation of theobromine, a methylxanthine in cocoa [2].
  • Some, such as Gr66a, are known to be expressed in neurons that mediate gustatory repulsion . painless mutants are not taste blind; they show normal aversive gustatory behavior with salt and quinine and attractive responses to sugars and capsaicin [3].
  • Mapping the axonal targets of cells expressing Gr66a and Gr5a reveals distinct projection patterns for these two groups of neurons in the brain [1].

Other interactions of Gr66a

  • These genes fall into two distinct groups: seven of them, including Gr66a, are expressed in 22 or fewer taste neurons in each labial palp [1].


  1. Taste perception and coding in Drosophila. Thorne, N., Chromey, C., Bray, S., Amrein, H. Curr. Biol. (2004) [Pubmed]
  2. A taste receptor required for the caffeine response in vivo. Moon, S.J., Köttgen, M., Jiao, Y., Xu, H., Montell, C. Curr. Biol. (2006) [Pubmed]
  3. Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1. Al-Anzi, B., Tracey, W.D., Benzer, S. Curr. Biol. (2006) [Pubmed]
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