The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Heteroxanthin     7-methyl-3H-purine-2,6-dione

Synonyms: Heteroxanthine, CHEMBL321248, SureCN235130, NSC-7861, ACMC-1AO0T, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Heteroxanthin


Psychiatry related information on Heteroxanthin


High impact information on Heteroxanthin


Chemical compound and disease context of Heteroxanthin


Biological context of Heteroxanthin


Anatomical context of Heteroxanthin


Associations of Heteroxanthin with other chemical compounds


Gene context of Heteroxanthin


Analytical, diagnostic and therapeutic context of Heteroxanthin


  1. Benign breast disease and consumption of beverages containing methylxanthines. La Vecchia, C., Franceschi, S., Parazzini, F., Regallo, M., Decarli, A., Gallus, G., Di Pietro, S., Tognoni, G. J. Natl. Cancer Inst. (1985) [Pubmed]
  2. Phase Ib trial of pentoxifylline and ciprofloxacin in patients treated with interleukin-2 and lymphokine-activated killer cell therapy for metastatic renal cell carcinoma. Thompson, J.A., Bianco, J.A., Benyunes, M.C., Neubauer, M.A., Slattery, J.T., Fefer, A. Cancer Res. (1994) [Pubmed]
  3. Cyclic AMP regulation of P0 glycoprotein and myelin basic protein gene expression in semi-differentiated peripheral neurinoma cell line D6P2T. Gandelman, K.Y., Pfeiffer, S.E., Carson, J.H. Development (1989) [Pubmed]
  4. 7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties. Ogawa, M., Herai, Y., Koizumi, N., Kusano, T., Sano, H. J. Biol. Chem. (2001) [Pubmed]
  5. Methylxanthine therapy and reversible airway obstruction. McFadden, E.R. Am. J. Med. (1985) [Pubmed]
  6. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Nehlig, A., Daval, J.L., Debry, G. Brain Res. Brain Res. Rev. (1992) [Pubmed]
  7. Postnatal caffeine exposure: effects on motor skills and locomotor activity during ontogenesis. Tchekalarova, J., Kubova, H., Mares, P. Behav. Brain Res. (2005) [Pubmed]
  8. Comparative toxicity of caffeine and aminophylline (theophylline ethylenediamine) in young and adult rats. Warszawski, D., Gorodischer, R., Kaplanski, J. Biol. Neonate (1978) [Pubmed]
  9. The influence of chronic caffeine administration on sleep parameters in the cat. Sinton, C.M., Petitjean, F. Pharmacol. Biochem. Behav. (1989) [Pubmed]
  10. Coffee intake and risk of hip fracture in women in northern Italy. Tavani, A., Negri, E., La Vecchia, C. Preventive medicine. (1995) [Pubmed]
  11. Dual inhibitory mechanism of secretin action on acid secretion in totally isolated, vascularly perfused rat stomach. Chung, I., Li, P., Lee, K., Chang, T., Chey, W.Y. Gastroenterology (1994) [Pubmed]
  12. Effect of caffeine on the human small intestine. Wald, A., Back, C., Bayless, T.M. Gastroenterology (1976) [Pubmed]
  13. Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase. Bergold, P.J., Sweatt, J.D., Winicov, I., Weiss, K.R., Kandel, E.R., Schwartz, J.H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  14. Mechanism of caffeine-induced checkpoint override in fission yeast. Moser, B.A., Brondello, J.M., Baber-Furnari, B., Russell, P. Mol. Cell. Biol. (2000) [Pubmed]
  15. Pentoxifylline promotes replication of human cytomegalovirus in vivo and in vitro. Staak, K., Prosch, S., Stein, J., Priemer, C., Ewert, R., Docke, W.D., Kruger, D.H., Volk, H.D., Reinke, P. Blood (1997) [Pubmed]
  16. Pharmacologic management of obstructive lung disease. Current perspectives. Skorodin, M.S. Am. J. Med. (1986) [Pubmed]
  17. Methylxanthines and breast cancer. Rohan, T.E., McMichael, A.J. Int. J. Cancer (1988) [Pubmed]
  18. Phase II study of theophylline in chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E4998). Wiernik, P.H., Paietta, E., Goloubeva, O., Lee, S.J., Makower, D., Bennett, J.M., Wade, J.L., Ghosh, C., Kaminer, L.S., Pizzolo, J., Tallman, M.S. Leukemia (2004) [Pubmed]
  19. Lisofylline sensitizes p53 mutant human ovarian carcinoma cells to the cytotoxic effects of cis-diamminedichloroplatinum (II). Husain, A., Rosales, N., Schwartz, G.K., Spriggs, D.R. Gynecol. Oncol. (1998) [Pubmed]
  20. Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure. Poggi, R., Brandolese, R., Bernasconi, M., Manzin, E., Rossi, A. Chest (1989) [Pubmed]
  21. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Dennis, P.B., Pullen, N., Kozma, S.C., Thomas, G. Mol. Cell. Biol. (1996) [Pubmed]
  22. Analysis of the kinetics of cyclic AMP hydrolysis by the cyclic GMP-stimulated cyclic nucleotide phosphodiesterase. Wada, H., Manganiello, V.C., Osborne, J.C. J. Biol. Chem. (1987) [Pubmed]
  23. A taste receptor required for the caffeine response in vivo. Moon, S.J., Köttgen, M., Jiao, Y., Xu, H., Montell, C. Curr. Biol. (2006) [Pubmed]
  24. Regulation of glycogen metabolism in astrocytoma and neuroblastoma cells in culture. Passonneau, J.V., Crites, S.K. J. Biol. Chem. (1976) [Pubmed]
  25. Regulation of tetrahydrobiopterin biosynthesis in cultured dopamine neurons by depolarization and cAMP. Zhu, M., Hirayama, K., Kapatos, G. J. Biol. Chem. (1994) [Pubmed]
  26. Effects of pentoxifylline pretreatment on Kupffer cells in rat liver transplantation. Kozaki, K., Egawa, H., Bermudez, L., Keefe, E.B., So, S.K., Esquivel, C.O. Hepatology (1995) [Pubmed]
  27. Methylxanthine bronchodilators potentiate multiple human neutrophil functions. Schmeichel, C.J., Thomas, L.L. J. Immunol. (1987) [Pubmed]
  28. Characterization of basal and methylxanthine-stimulated Ca2+ transport in abalone spermatozoa. Kopf, G.S., Lewis, C.A., Vacquier, V.D. J. Biol. Chem. (1984) [Pubmed]
  29. Pentoxifylline prevents indomethacin induced acute gastric mucosal damage in rats: role of tumour necrosis factor alpha. Santucci, L., Fiorucci, S., Giansanti, M., Brunori, P.M., Di Matteo, F.M., Morelli, A. Gut (1994) [Pubmed]
  30. Pentoxifylline inhibition of procoagulant activity generated by activated mononuclear phagocytes. De Prost, D., Ollivier, V., Hakim, J. Mol. Pharmacol. (1990) [Pubmed]
  31. Reduced responsiveness of adenylate cyclase in alveolar macrophages from patients with asthma. Bachelet, M., Vincent, D., Havet, N., Marrash-Chahla, R., Pradalier, A., Dry, J., Vargaftig, B.B. J. Allergy Clin. Immunol. (1991) [Pubmed]
  32. Theobromine kinetics and metabolic disposition. Tarka, S.M., Arnaud, M.J., Dvorchik, B.H., Vesell, E.S. Clin. Pharmacol. Ther. (1983) [Pubmed]
  33. Pharmacokinetic drug interactions with antimicrobial agents. Gillum, J.G., Israel, D.S., Polk, R.E. Clinical pharmacokinetics. (1993) [Pubmed]
  34. Pentoxifylline inhibits hypoxia-induced upregulation of tumor cell tissue factor and vascular endothelial growth factor. Amirkhosravi, A., Meyer, T., Warnes, G., Amaya, M., Malik, Z., Biggerstaff, J.P., Siddiqui, F.A., Sherman, P., Francis, J.L. Thromb. Haemost. (1998) [Pubmed]
  35. Enhancement of bone morphogenetic protein-2-induced new bone formation in mice by the phosphodiesterase inhibitor pentoxifylline. Horiuchi, H., Saito, N., Kinoshita, T., Wakabayashi, S., Tsutsumimoto, T., Takaoka, K. Bone (2001) [Pubmed]
  36. Enhanced release of interleukin-10 and soluble tumor necrosis factor receptors as novel principles of methylxanthine action in murine models of endotoxic shock. Jilg, S., Barsig, J., Leist, M., Küsters, S., Volk, H.D., Wendel, A. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  37. Pentoxifylline in vivo down-regulates the release of IL-1 beta, IL-6, IL-8 and tumour necrosis factor-alpha by human peripheral blood mononuclear cells. Neuner, P., Klosner, G., Schauer, E., Pourmojib, M., Macheiner, W., Grünwald, C., Knobler, R., Schwarz, A., Luger, T.A., Schwarz, T. Immunology (1994) [Pubmed]
  38. Lack of association between slow acetylator status and spontaneous lupus erythematosus. Kumana, C.R., Chan, M.M., Wong, K.L., Wong, R.W., Kou, M., Lauder, I.J. Clin. Pharmacol. Ther. (1990) [Pubmed]
  39. Sympathomimetic effects of paraxanthine and caffeine in humans. Benowitz, N.L., Jacob, P., Mayan, H., Denaro, C. Clin. Pharmacol. Ther. (1995) [Pubmed]
  40. Methylxanthines and breast cancer. Schairer, C., Brinton, L.A., Hoover, R.N. Int. J. Cancer (1987) [Pubmed]
  41. Dual regulation by cAMP of beta-hexosaminidase-induced mitogenesis in bovine tracheal myocytes. Lew, D.B., Nebigil, C., Malik, K.U. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  42. Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration. Kelleher, D.K., Thews, O., Vaupel, P. Int. J. Radiat. Oncol. Biol. Phys. (1998) [Pubmed]
WikiGenes - Universities