Gene Review:
sox4b - SRY (sex determining region Y)-box 4b
Danio rerio
Synonyms:
SO:0000704
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High impact information on sox4b
- Transcripts of sox4b were detected in mid-trunk endoderm from the 5-somite stage, well before the onset of expression of the early pancreatic gene pdx-1 [1].
- Taken together, these data demonstrate that, in zebrafish, sox4b is expressed transiently during endocrine cell differentiation and plays a crucial role in the generation of alpha endocrine cells [1].
- sox4b is a key player of pancreatic alpha cell differentiation in zebrafish [1].
- The involvement of sox4b in cell differentiation is suggested firstly by its up-regulation in mind bomb mutant embryos displaying accelerated pancreatic cell differentiation [1].
Analytical, diagnostic and therapeutic context of sox4b
- Furthermore, by fluorescent double in situ hybridization, we found that expression of sox4b is mostly restricted to precursors of the endocrine compartment [1].
References
- sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Mavropoulos, A., Devos, N., Biemar, F., Zecchin, E., Argenton, F., Edlund, H., Motte, P., Martial, J.A., Peers, B. Dev. Biol. (2005) [Pubmed]
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