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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pdx1  -  pancreatic and duodenal homeobox 1

Danio rerio

Synonyms: SO:0000704, ipf1, pdx-1, zgc:100874
 
 
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High impact information on pdx1

  • Zebrafish embryos compromised in Hh signaling exhibit disruption in the expression of the pancreas-specifying homeobox gene pdx-1 and concomitantly show almost complete absence of the endocrine pancreas [1].
  • Transcripts of sox4b were detected in mid-trunk endoderm from the 5-somite stage, well before the onset of expression of the early pancreatic gene pdx-1 [2].
  • Within the endoderm, ptf1a is initially expressed at 32 hpf in the ventral portion of the pdx1 expression domain; ptf1a is expressed in a subset of cells located on the left side of the embryo posteriorly to the liver primordium and anteriorly to the endocrine islet that arises from the posterodorsal pancreatic anlage [3].
  • Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell [4].

References

  1. Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Roy, S., Qiao, T., Wolff, C., Ingham, P.W. Curr. Biol. (2001) [Pubmed]
  2. sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Mavropoulos, A., Devos, N., Biemar, F., Zecchin, E., Argenton, F., Edlund, H., Motte, P., Martial, J.A., Peers, B. Dev. Biol. (2005) [Pubmed]
  3. Evolutionary conserved role of ptf1a in the specification of exocrine pancreatic fates. Zecchin, E., Mavropoulos, A., Devos, N., Filippi, A., Tiso, N., Meyer, D., Peers, B., Bortolussi, M., Argenton, F. Dev. Biol. (2004) [Pubmed]
  4. Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Yee, N.S., Yusuff, S., Pack, M. Genesis (2001) [Pubmed]
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