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Gene Review

Est-P  -  Esterase P

Drosophila melanogaster

Synonyms: CG17148, Carboxylesterase-P, Carboxylic-ester hydrolase P, Dmel\CG17148, EST-5, ...
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Disease relevance of Est-P

  • Expression of EstP using the Baculovirus system led to production of a carboxylesterase biochemically indistinguishable from EST7 [1].

High impact information on Est-P

  • In addition, there are striking similarities to patterns of variation observed at the Est6 and Est-P loci, which are located approximately 1,000 kb from Sod [2].
  • EST 5 is expressed in the eyes and hemolymph of transformed D. melanogaster just as it is in D. pseudoobscura, but it is not detectable in the ejaculatory duct, where the homologous enzyme, EST 6, is most abundant [3].
  • Southern and Northern blot hybridization analyses of the 20-kb region surrounding the Est-6/Est-P duplication failed to detect any other duplicated esterase genes, although this region is actively transcribed [4].
  • This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. melanogaster [5].
  • Finally, introduction of a wild-type copy of EstP by germline transformation into the variant strain confers the wild-type EST7 phenotype [1].

Biological context of Est-P

  • Nucleotide sequences of the coding regions of the three D. pseudoobscura genes showed 78-85% similarity in pairwise comparisons, whereas the relatedness between Est-6 and Est-P was only 67% [6].

Other interactions of Est-P

  • Further sequencing revealed the presence of a tandem duplication of the Est-6 gene (denoted Est-P) which also has an exon of 1,387 bp and an exon of 248 bp, separated by a short intron of 56 bp [4].


  1. Characterization of the EstP protein in Drosophila melanogaster and its conservation in drosophilids. Dumancic, M.M., Oakeshott, J.G., Russell, R.J., Healy, M.J. Biochem. Genet. (1997) [Pubmed]
  2. DNA variation at the Sod locus of Drosophila melanogaster: an unfolding story of natural selection. Hudson, R.R., Sáez, A.G., Ayala, F.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Molecular analysis of evolutionary changes in the expression of Drosophila esterases. Brady, J.P., Richmond, R.C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Molecular analysis of duplicated esterase genes in Drosophila melanogaster. Collet, C., Nielsen, K.M., Russell, R.J., Karl, M., Oakeshott, J.G., Richmond, R.C. Mol. Biol. Evol. (1990) [Pubmed]
  5. Is esterase-P encoded by a cryptic pseudogene in Drosophila melanogaster? Balakirev, E.S., Ayala, F.J. Genetics (1996) [Pubmed]
  6. An evolutionary model for the duplication and divergence of esterase genes in Drosophila. Brady, J.P., Richmond, R.C. J. Mol. Evol. (1992) [Pubmed]
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