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Gene Review

alpha-Est1  -  alpha-Esterase-1

Drosophila melanogaster

Synonyms: Alpha-Est1, CG1031, DmalphaE1, Dmel\CG1031, Est1, ...
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Disease relevance of alpha-Est1

  • Unexpectedly, ES links together non-LTR retrotransposons and single-stranded RNA viruses like influenza C and coronaviruses, which are known to depend on their own ES [1].

Psychiatry related information on alpha-Est1

  • Our observations agree with previous results for D. melanogaster and provide additional support to our hypothesis that after the duplication event Est-6 retained the esterase-coding function and its role during copulation, while psiEst-6 lost that function but now operates in conjunction with Est-6 as an intergene [2].

High impact information on alpha-Est1

  • Here we present the crystal structure of a Drosophila PERIOD (dPER) fragment comprising two tandemly organized PAS (PER-ARNT-SIM) domains (PAS-A and PAS-B) and two additional C-terminal alpha helices (alphaE and alphaF) [3].
  • Neurotactin has a large cytoplasmic domain rich in charged residues and an extracellular domain similar to cholinesterase that lacks the active site serine required for esterase activity [4].
  • The gene for the esterase S isozyme complex (estS) has been localized in band 2G5e of chromosome II [5].
  • The cloning and expression of the gene encoding organ-specific esterase S from the genome of Drosophila virilis [5].
  • In both cases, esterase S is synthesized in the oocytes, and the major part of the protein is transported from the oocytes and accumulated in the incubation medium [5].

Biological context of alpha-Est1


Anatomical context of alpha-Est1

  • Integrins of the beta7 subfamily, alpha4 beta7 and alphaE beta7, contribute to lymphocyte homing and to the development of protective or autoreactive immune responses at mucosal sites [11].
  • Finally, we show that the 64kDa protein of human semen reveals positive cross-reactivity with antibodies directed against Mytilus MAP and Drosophila esterase S [12].
  • Mussel MAP, a major gonad-duct esterase-like protein, is released into sea water as a dual constituent of the seminal fluid and the spermatozoon [12].
  • The present study focused on this problem and report our observations on biochemical characteristics of male-associated polypeptide (MAP) identified in the gonad tissue of bivalve molluscs, Mytilus galloprovincialis, in comparison to those of male-specific carboxylesterase (esterase S) of Drosophila virilis ejaculatory bulbs [13].
  • This esterase is contained in male genitalia only, predominantly in the ejaculatory bulb (waxy plug) [14].

Associations of alpha-Est1 with chemical compounds


Other interactions of alpha-Est1


Analytical, diagnostic and therapeutic context of alpha-Est1


  1. The esterase and PHD domains in CR1-like non-LTR retrotransposons. Kapitonov, V.V., Jurka, J. Mol. Biol. Evol. (2003) [Pubmed]
  2. Entropy and GC Content in the beta-esterase gene cluster of the Drosophila melanogaster subgroup. Balakirev, E.S., Chechetkin, V.R., Lobzin, V.V., Ayala, F.J. Mol. Biol. Evol. (2005) [Pubmed]
  3. Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD. Yildiz, O., Doi, M., Yujnovsky, I., Cardone, L., Berndt, A., Hennig, S., Schulze, S., Urbanke, C., Sassone-Corsi, P., Wolf, E. Mol. Cell (2005) [Pubmed]
  4. Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases. de la Escalera, S., Bockamp, E.O., Moya, F., Piovant, M., Jiménez, F. EMBO J. (1990) [Pubmed]
  5. The cloning and expression of the gene encoding organ-specific esterase S from the genome of Drosophila virilis. Yenikolopov, G.N., Kuzin, B.A., Evgen'ev, N.B., Ludwig, M.Z., Korochkin, L.I., Georgiev, G.P. EMBO J. (1983) [Pubmed]
  6. The evolution of an alpha-esterase pseudogene inactivated in the Drosophila melanogaster lineage. Robin, G.C., Russell, R.J., Cutler, D.J., Oakeshott, J.G. Mol. Biol. Evol. (2000) [Pubmed]
  7. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin, C., Russell, R.J., Medveczky, K.M., Oakeshott, J.G. J. Mol. Evol. (1996) [Pubmed]
  8. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Russell, R.J., Robin, G.C., Kostakos, P., Newcomb, R.D., Boyce, T.M., Medveczky, K.M., Oakeshott, J.G. Insect Biochem. Mol. Biol. (1996) [Pubmed]
  9. Divergent and conserved features in the spatial expression of the Drosophila pseudoobscura esterase-5B gene and the esterase-6 gene of Drosophila melanogaster. Tamarina, N.A., Ludwig, M.Z., Richmond, R.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Extent of genetic variation at a highly polymorphic esterase locus in Drosophila pseudoobscura. Coyne, J.A., Felton, A.A., Lewontin, R.C. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  11. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. Rietzler, M., Bittner, M., Kolanus, W., Schuster, A., Holzmann, B. J. Biol. Chem. (1998) [Pubmed]
  12. Mussel MAP, a major gonad-duct esterase-like protein, is released into sea water as a dual constituent of the seminal fluid and the spermatozoon. Torrado, M., Paz, M., Korochkin, L.I., Mikhailov, A.T. J. Exp. Biol. (2003) [Pubmed]
  13. Male-predominant carboxylesterase expression in the reproductive system of molluscs and insects: immunochemical and biochemical similarity between Mytilus male associated polypeptide (MAP) and Drosophila sex-specific esterase S. Mikhailov, A.T., Torrado, M., Korochkin, L.I., Kopantzeva, M.A., Méndez, J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1997) [Pubmed]
  14. Genetics of esterases in Drosophila. IV. Slow-migrating S-esterase in Drosophila of the virilis group. Korochkin, L.I., Belyaeva, E.S., Matveeva, N.M., Kuzin, B.A., Serov, O.L. Biochem. Genet. (1976) [Pubmed]
  15. Structural comparison of two esterases from Drosophila mojavensis isolated by immunoaffinity chromatography. Pen, J., Van Beeumen, J., Beintema, J.J. Biochem. J. (1986) [Pubmed]
  16. A comparison of Drosophila melanogaster detoxification gene induction responses for six insecticides, caffeine and phenobarbital. Willoughby, L., Chung, H., Lumb, C., Robin, C., Batterham, P., Daborn, P.J. Insect Biochem. Mol. Biol. (2006) [Pubmed]
  17. Genetics of esterases in Drosophila. IX. Characterization of the JH-esterase in D. virilis. Rauschenbach IYu, n.u.l.l., Lukashina, N.S., Budker, V.G., Korochkin, L.I. Biochem. Genet. (1987) [Pubmed]
  18. Molecular analysis of duplicated esterase genes in Drosophila melanogaster. Collet, C., Nielsen, K.M., Russell, R.J., Karl, M., Oakeshott, J.G., Richmond, R.C. Mol. Biol. Evol. (1990) [Pubmed]
  19. Isolation of alpha cluster esterase genes associated with organophosphate resistance in Lucilia cuprina. Newcomb, R.D., East, P.D., Russell, R.J., Oakeshott, J.G. Insect Mol. Biol. (1996) [Pubmed]
  20. In vivo phosphorylation of Drosophila melanogaster nuclear lamins during both interphase and mitosis. Rzepecki, R., Fisher, P.A. Cell. Mol. Biol. Lett. (2002) [Pubmed]
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