Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

sti - sticky

Drosophila melanogaster

Synonyms: CG10522, CIT-K, Citron K, DCK, Dmel\CG10522, ...

Shandala, T. et al., D'Avino, P.P. et al., Naim, V. et al., Dean, S.O. et al.

D'Avino, Savoian, Glover,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on sti

RNA interference-mediated silencing of sti in cultured cells causes them to become multinucleate [1].
Here, we report the identification and analysis of a novel Drosophila gene, sticky (sti), essential for cytokinesis in all fly proliferating tissues. sti encodes the Drosophila orthologue of the mammalian Citron kinase [1].
Here we report that the Drosophila citron gene encodes an essential effector kinase of Pbl-RhoA signalling in vivo [2].
Strong genetic interactions were observed between citron and pbl alleles and constructs [2].
Phenotypic analysis of mutants showed that citron is required for cytokinesis in every tissue examined, with mutant cells exhibiting multinucleate and hyperploid phenotypes [2].

Biological context of sti

Drosophila citron kinase is required for the final steps of cytokinesis [3].

Other interactions of sti

Furthermore, the essential role of Citron in cytokinesis is not phosphorylation of the RLC [4].

References

Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. D'Avino, P.P., Savoian, M.S., Glover, D.M. J. Cell Biol. (2004) [Pubmed]
Citron kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster. Shandala, T., Gregory, S.L., Dalton, H.E., Smallhorn, M., Saint, R. Development (2004) [Pubmed]
Drosophila citron kinase is required for the final steps of cytokinesis. Naim, V., Imarisio, S., Di Cunto, F., Gatti, M., Bonaccorsi, S. Mol. Biol. Cell (2004) [Pubmed]
Rho Kinase's Role in Myosin Recruitment to the Equatorial Cortex of Mitotic Drosophila S2 Cells Is for Myosin Regulatory Light Chain Phosphorylation. Dean, S.O., Spudich, J.A. PLoS ONE (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP006932	Anopheles gambiae str. PEST
CIT	Bos taurus
CIT	Canis lupus familiaris
cit	Danio rerio
CIT	Gallus gallus
CIT	Homo sapiens
CIT	Macaca mulatta
Cit	Mus musculus
CIT	Pan troglodytes
Cit	Rattus norvegicus
cit	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.