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Gene Review

Cit  -  citron

Mus musculus

Synonyms: C030025P15Rik, CRIK, CRIK-SK, Cit-k, Citron Rho-interacting kinase, ...
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Disease relevance of Cit

  • Using constitutively active and dominant negative mutants, we showed that citron kinase is involved in the morphologic differentiation of N1E-115 neuroblastoma cells induced by serum starvation [1].

High impact information on Cit


Biological context of Cit


Anatomical context of Cit

  • Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes [8].
  • In citron kinase null mutants, a large proportion of neuronal cells within neocortex are binucleate; however, very few glial cells are binucleate [6].
  • Our data indicate that Citron kinase is specifically required for cytokinesis of the male germ line [7].
  • More importantly, quantitative analysis of citron kinase knockout cerebral cortex displayed that this molecule may differentially regulate the morphology of the dendritic compartment in corticocollicular versus callosally-projecting pyramidal neurons [1].
  • Citron colocalization with PSD-95 occurred, not exclusively but certainly, at glutamatergic synapses in a limited set of neurons, such as the thalamic excitatory neurons; Citron expression, however, could not be detected in the principal neurons of the hippocampus and the cerebellum in the adult mouse brain [5].

Associations of Cit with chemical compounds

  • Since there is no known codon for citrulline, we have constructed a mutant form of recombinant murine MBP (rmMBP) in which 5 Arg and 1 Lys residues have been replaced by Gln as the most reasonable analogue of Cit [9].

Other interactions of Cit


  1. Role of citron kinase in dendritic morphogenesis of cortical neurons. Di Cunto, F., Ferrara, L., Curtetti, R., Imarisio, S., Guazzone, S., Broccoli, V., Bulfone, A., Altruda, F., Vercelli, A., Silengo, L. Brain Res. Bull. (2003) [Pubmed]
  2. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Madaule, P., Eda, M., Watanabe, N., Fujisawa, K., Matsuoka, T., Bito, H., Ishizaki, T., Narumiya, S. Nature (1998) [Pubmed]
  3. Human Vam6p promotes lysosome clustering and fusion in vivo. Caplan, S., Hartnell, L.M., Aguilar, R.C., Naslavsky, N., Bonifacino, J.S. J. Cell Biol. (2001) [Pubmed]
  4. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Hecker, M., Sessa, W.C., Harris, H.J., Anggård, E.E., Vane, J.R. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  5. Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. Furuyashiki, T., Fujisawa, K., Fujita, A., Madaule, P., Uchino, S., Mishina, M., Bito, H., Narumiya, S. J. Neurosci. (1999) [Pubmed]
  6. Citron kinase is a regulator of mitosis and neurogenic cytokinesis in the neocortical ventricular zone. LoTurco, J.J., Sarkisian, M.R., Cosker, L., Bai, J. Cereb. Cortex (2003) [Pubmed]
  7. Essential role of citron kinase in cytokinesis of spermatogenic precursors. Cunto, F.D., Imarisio, S., Camera, P., Boitani, C., Altruda, F., Silengo, L. J. Cell. Sci. (2002) [Pubmed]
  8. Citron kinase is a cell cycle-dependent, nuclear protein required for G2/M transition of hepatocytes. Liu, H., Di Cunto, F., Imarisio, S., Reid, L.M. J. Biol. Chem. (2003) [Pubmed]
  9. An Arg/Lys-->Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis. Bates, I.R., Libich, D.S., Wood, D.D., Moscarello, M.A., Harauz, G. Protein Expr. Purif. (2002) [Pubmed]
  10. Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules. Fujisawa, K., Madaule, P., Ishizaki, T., Watanabe, G., Bito, H., Saito, Y., Hall, A., Narumiya, S. J. Biol. Chem. (1998) [Pubmed]
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