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Gene Review:

cdk1 - cyclin-dependent kinase 1

Xenopus (Silurana) tropicalis

Synonyms: PSTAIR, cdc-2, cdc2, cdc28a, cdc2x1.1, ...

Pickham, K.M. et al., Dunphy, W.G. et al., Roy, L.M. et al., Dunphy, W.G. et al.

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High impact information on cdc2

Previous studies from this laboratory have shown that purified MPF from Xenopus eggs contains cyclin B2 complexed with cdc2 kinase [1].
We show that the Xenopus cdc2 protein is phosphorylated on tyrosine in vivo, and that this tyrosine phosphorylation varies markedly with the stage of the cell cycle [2].
Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase [2].
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis [3].
Previously, we demonstrated that simultaneous mutation of Thr14-->Ala14 and Tyr15-->Phe15 in the Xenopus cdc2 protein results in an activated cdc2 mutant that induces maturation in resting oocytes [4].

Anatomical context of cdc2

Mutants at Ser277 of Xenopus cdc2 protein kinase induce oocyte maturation in the absence of the positive regulatory phosphorylation site Thr161 [4].

References

The cyclin B2 component of MPF is a substrate for the c-mos(xe) proto-oncogene product. Roy, L.M., Singh, B., Gautier, J., Arlinghaus, R.B., Nordeen, S.K., Maller, J.L. Cell (1990) [Pubmed]
Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase. Dunphy, W.G., Newport, J.W. Cell (1989) [Pubmed]
The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Dunphy, W.G., Brizuela, L., Beach, D., Newport, J. Cell (1988) [Pubmed]
Mutants at Ser277 of Xenopus cdc2 protein kinase induce oocyte maturation in the absence of the positive regulatory phosphorylation site Thr161. Pickham, K.M., Donoghue, D.J. Mol. Biol. Cell (1994) [Pubmed]

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