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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cdk1  -  cyclin-dependent kinase 1

Danio rerio

Synonyms: SO:0000704, cdc2, wu:fc30e01, zgc:92032
 
 
 
 
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High impact information on cdc2

  • These results, which are identical to those in goldfish, strongly suggest that cyclin B is synthesized from stored (masked) mRNA after 17alpha,20beta-DP stimulation and that its binding to the preexisting cdc2 allows cdk7 to activate MPF [1].
 

Biological context of cdc2

  • When treated with 17alpha,20beta-dihydroxy-4-pregnen-3-one (17alpha,20beta-DP), a natural maturation-inducing hormone in fishes, fully grown zebrafish oocytes are induced to mature via the activation of the maturation-promoting factor (MPF), which consists of cdc2 (a catalytic subunit) and cyclin B (a regulatory subunit) [1].

References

  1. Introduction of cyclin B induces activation of the maturation-promoting factor and breakdown of germinal vesicle in growing zebrafish oocytes unresponsive to the maturation-inducing hormone. Kondo, T., Yanagawa, T., Yoshida, N., Yamashita, M. Dev. Biol. (1997) [Pubmed]
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