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Gene Review

ccnb2  -  cyclin B2

Xenopus (Silurana) tropicalis

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Disease relevance of Ccnb2


High impact information on Ccnb2

  • Previous studies from this laboratory have shown that purified MPF from Xenopus eggs contains cyclin B2 complexed with cdc2 kinase [1].
  • Moreover, ablation of c-mos(xe) from oocytes by antisense oligonucleotide injection reduces the rate of cyclin B2 phosphorylation in oocyte extracts by 40% [1].
  • The cyclin B2 component of MPF is a substrate for the c-mos(xe) proto-oncogene product [1].
  • The licence to replicate is given by Cdc6 at the end of meiosis I, but the cytostatic factor (CSF) pathway, which maintains large amounts of active Cdc2/Cyclin B2, prevents the entry into S phase until fertilization [3].
  • Using a polyclonal antibody raised against B2 cyclin from Xenopus laevis, we show that prophase-arrested Xenopus oocytes contain a stockpile of cyclin B2 protein [4].

Biological context of Ccnb2


Anatomical context of Ccnb2


Associations of Ccnb2 with chemical compounds


Other interactions of Ccnb2

  • Microtubule-associated protein (MAP) kinase from Xenopus eggs phosphorylated cyclin B1 significantly at Ser-94 or Ser-96, whereas it was largely inactive against cyclin B2 [12].

Analytical, diagnostic and therapeutic context of Ccnb2


  1. The cyclin B2 component of MPF is a substrate for the c-mos(xe) proto-oncogene product. Roy, L.M., Singh, B., Gautier, J., Arlinghaus, R.B., Nordeen, S.K., Maller, J.L. Cell (1990) [Pubmed]
  2. Initiation of translation of human rhinovirus RNA: mapping the internal ribosome entry site. Borman, A., Jackson, R.J. Virology (1992) [Pubmed]
  3. Competence to replicate in the unfertilized egg is conferred by Cdc6 during meiotic maturation. Lemaître, J.M., Bocquet, S., Méchali, M. Nature (2002) [Pubmed]
  4. Cyclin B in Xenopus oocytes: implications for the mechanism of pre-MPF activation. Gautier, J., Maller, J.L. EMBO J. (1991) [Pubmed]
  5. Evidence that Mos protein may not act directly on cyclin. Xu, W., Ladner, K.J., Smith, L.D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe. Freeman, R.S., Ballantyne, S.M., Donoghue, D.J. Mol. Cell. Biol. (1991) [Pubmed]
  7. Mitotic effects of a constitutively active mutant of the Xenopus polo-like kinase Plx1. Qian, Y.W., Erikson, E., Maller, J.L. Mol. Cell. Biol. (1999) [Pubmed]
  8. Zygotic regulation of maternal cyclin A1 and B2 mRNAs. Audic, Y., Anderson, C., Bhatty, R., Hartley, R.S. Mol. Cell. Biol. (2001) [Pubmed]
  9. On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis. Kobayashi, H., Minshull, J., Ford, C., Golsteyn, R., Poon, R., Hunt, T. J. Cell Biol. (1991) [Pubmed]
  10. MPF is activated in growing immature Xenopus oocytes in the absence of detectable tyrosine dephosphorylation of P34cdc2. Rime, H., Yang, J., Jessus, C., Ozon, R. Exp. Cell Res. (1991) [Pubmed]
  11. Identification of cyk, a cyclin B2 kinase, as a novel calcium/calmodulin-dependent protein kinase II and its role during Xenopus laevis oocyte maturation. Stevens, I., Derua, R., Rondelez, E., Waelkens, E., Merlevede, W., Goris, J. Exp. Cell Res. (1999) [Pubmed]
  12. Phosphorylation of Xenopus cyclins B1 and B2 is not required for cell cycle transitions. Izumi, T., Maller, J.L. Mol. Cell. Biol. (1991) [Pubmed]
  13. Cyclin is a component of maturation-promoting factor from Xenopus. Gautier, J., Minshull, J., Lohka, M., Glotzer, M., Hunt, T., Maller, J.L. Cell (1990) [Pubmed]
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