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Gene Review

CD40LG  -  CD40 ligand

Gallus gallus

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High impact information on CD40LG

  • These data suggest a possible role for CD40-CD40L interactions during EMT and the remodeling of the aorta [1].
  • CD40-CD40L expression was found on endothelial cells (ECs), mesenchymal cells, and smooth muscle cells (SMCs) at all stages examined, and appeared to be distributed across the aortic wall [1].

Biological context of CD40LG

  • Given the important role played by the CD40-CD40 ligand (CD40L) system during the initiation and progress of atherosclerosis, we investigated whether both CD40 and CD40L were present in the aortic wall during EMT and the advanced stages of chicken embryo development [1].

Analytical, diagnostic and therapeutic context of CD40LG


  1. CD40 and CD40L expression in the chicken embryo aorta: possible role in the endothelial-mesenchymal transdifferentiation process. Arciniegas, E., Becerra, A., De Sanctis, J.B., Graterol, A., Ramírez, R. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2003) [Pubmed]
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