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Gene Review

CD40LG  -  CD40 ligand

Bos taurus

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High impact information on TNFSF5

  • This was not related to binding of CTLA4Ig or CD40L fusion proteins, implying similar levels of expression of their ligands, CD80 and CD86 or CD40 [1].
  • In this study, we used murine CD154 (CD40 ligand) and gamma-chain-common cytokines to support the growth of B cells isolated from ovine lymphoid tissues [2].
  • Of these, 11 genes showed significant up regulation (fold change, >1.5; P < 0.1) across both animals, including those encoding bovine CD40L, several matrix metalloproteinases, and SPARC (secreted protein, acidic and rich in cystine) [3].
  • Interestingly, in the presence of CD40 ligand, sIgM-mediated induction of CD5 on B cells was inhibited [4].
  • We investigated bovine CD40L mRNA expression in established T cell clones by RT-PCR and Southern blotting [5].

Other interactions of TNFSF5

  • The co-administration of costimulatory molecules CD80 (B7-1), CD86 (B7-2) and CD154 (CD40L) has been shown to enhance immune responses in several murine models [6].


  1. Identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate T cells. Howard, C.J., Sopp, P., Brownlie, J., Kwong, L.S., Parsons, K.R., Taylor, G. J. Immunol. (1997) [Pubmed]
  2. CD154 costimulated ovine primary B cells, a cell culture system that supports productive infection by bovine leukemia virus. Van den Broeke, A., Cleuter, Y., Beskorwayne, T., Kerkhofs, P., Szynal, M., Bagnis, C., Burny, A., Griebel, P. J. Virol. (2001) [Pubmed]
  3. Gene expression profiling of peripheral blood mononuclear cells from cattle infected with Mycobacterium paratuberculosis. Coussens, P.M., Colvin, C.J., Wiersma, K., Abouzied, A., Sipkovsky, S. Infect. Immun. (2002) [Pubmed]
  4. Activation of bovine B cells via surface immunoglobulin M cross-linking or CD40 ligation results in different B-cell phenotypes. Haas, K.M., Estes, D.M. Immunology (2000) [Pubmed]
  5. Kinetics of expression and subset distribution of the TNF superfamily members CD40 ligand and Fas ligand on T lymphocytes in cattle. Hirano, A., Brown, W.C., Trigona, W., Tuo, W., Estes, D.M. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  6. CD80 and CD86, but not CD154, augment DNA vaccine-induced protection in experimental bovine tuberculosis. Maue, A.C., Waters, W.R., Palmer, M.V., Whipple, D.L., Minion, F.C., Brown, W.C., Estes, D.M. Vaccine (2004) [Pubmed]
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